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TranscriptomicsIdentification of cranial-specific neural crest genes by comparative transcriptomics
We employ RNA-seq of FACS sorted cell populations to identify genes that are enriched in cranial neural crest in relationship to the trunk. Transcriptional profiling of delaminating cranial and trunk neural crest subpopulations.
ORGANISM(S): Gallus gallus 
2016-06-24 | E-GEOD-75125 | biostudies-arrayexpress
TranscriptomicsPax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers [Xenopus_laevis]
Neural crest development is orchestrated by a complex and still poorly understood gene regulatory network. Premigratory neural crest is induced at the lateral border of the neural plate by the combined action of signaling molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1. Among th...
ORGANISM(S): Xenopus laevis 
2013-12-28 | E-GEOD-53678 | biostudies-arrayexpress
TranscriptomicsIsolation and transcriptional profiling of embryonic human neural crest cells
To identify new candidate genes for neurocristopathies, a Long-SAGE library has been made from human neural crest cells (hNCC) derived from a normal embryo at Carnegie stage 13. Data analysis indicates the expression of a number of genes in multiple GO functional classes that were anticipated based...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-GEOD-8368 | biostudies-arrayexpress
TranscriptomicsEmbryonic and adult neural crest stem cells
Cells were isolated from mouse embryonic neural crest stem cells at culture day 2 (NCSC), from day 7 in vitro differentiated progeny (NCP) and day 2 epidermal neural crest stem cells from bulge explants of adult whisker follicles (EPI-NCSC). Keywords: LongSAGE embryonic neural crest stem cells at cu...
ORGANISM(S): Mus musculus 
2006-04-18 | E-GEOD-4680 | biostudies-arrayexpress
TranscriptomicsNotch signaling regulates neural crest differentiation from human pluripotent stem cells
The aim of the dataset was to study on genome-wide level the effect of Notch inhibition in gene expression on neural crest differentiation of human embryonic stem cells under chemically defined conditions. Total RNA from hESCs, hESC-derived neural crest, hESC-derived neural crest+DAPT, and hESC-deri...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-53203 | biostudies-arrayexpress
TranscriptomicsPax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers [X_laevis_2]
Neural crest development is orchestrated by a complex and still poorly understood gene regulatory network. Premigratory neural crest is induced at the lateral border of the neural plate by the combined action of signaling molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1. Among th...
ORGANISM(S): Xenopus laevis 
2013-12-28 | E-GEOD-53677 | biostudies-arrayexpress
TranscriptomicsNorepinephrine transporter-deficient neural crest cells
Background: The goal of this study was to determine the transcriptional consequences of norepinephrine transporter (NET) gene deletion in noradrenergic neuron differentiation. The norepinephrine transporter (NET) is the target of powerful mind-altering substances, such as tricyclic antidepressants a...
ORGANISM(S): Mus musculus 
2008-06-23 | E-GEOD-11788 | biostudies-arrayexpress
ProteomicsGlobal ubiquitinome profiling identify Nedd4 as aregulator of Profilin 1 and actin remodeling in neural crest cells
We utilized quantitative analyses of the proteome, transcriptome, and ubiquitinome to study how ubiquitination and NEDD4 control neural crest cell survival and stem-cell-like properties. We report 276 novel NEDD4 targets in neural crest cells and show that loss of NEDD4 leads to a striking global r...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-08 | PXD024103 | Pride
Nedd4 Ubiquitin remnant enrichment Mouse Neural crest 
GenomicsRole of DNMT3B in the regulation of early neural and neural crest specifiers
The de novo DNA methyltransferase DNMT3B functions in establishing DNA methylation patterns during development. We performed RNAi knockdown of DNMT3B in human embryonic stem cells (ESCs) in order to investigate the mechanistic contribution of DNMT3B on DNA methylation and early neuronal differentiat...
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-32268 | biostudies-arrayexpress
TranscriptomicsADAM13 knockdown in Xenopus laevis cranial neural crest
ADAMs are transmembrane metalloproteases that control cell behavior by cleaving both cell adhesion and signaling molecules. The cytoplasmic domain of ADAMs can regulate the proteolytic activity by controlling the subcellular localization and/or the activation of the protease domain. Here we show tha...
ORGANISM(S): Xenopus laevis 
2011-02-22 | E-GEOD-21517 | biostudies-arrayexpress
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