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ProteomicsStructural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins
Nedd4-2 E3 ligase regulates Na+ homeostasis by ubiquitinating various channels and membrane transporters, including the epithelial sodium channel ENaC. In turn, Nedd4-2 dysregulation leads to various conditions, including electrolytic imbalance, respiratory distress, hypertension, and kidney disease...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PXD058899 | Pride
Saxs Calcium Protein-protein interaction H/d exchange Cryo-em Nedd4-2 14-3-3 proteins 
Proteomicsmouse Nedd4-2 KO and control tissue
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mi...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD011120 | Pride
Nedd4-2 
TranscriptomicsRNA-sequencing of Nedd4+/+ and Nedd4-/- mouse splenic B cells
Programmed mutagenesis of the immunoglobulin locus of B-lymphocytes during class switch recombination and somatic hypermutation requires RNA polymerase II (RNA polII) transcription complex dependent targeting of the DNA mutator, Activation Induced cytidine Deaminase (AID). AID deaminates cytidine re...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-49027 | biostudies-arrayexpress
ProteomicsPRM detection of NEDD4-2 in human IPF and control tissue
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mi...
ORGANISM(S): Homo sapiens (Human) 
2020-03-20 | PXD011129 | Pride
Nedd4-2 Ipf 
ProteomicsGlobal ubiquitinome profiling identify Nedd4 as aregulator of Profilin 1 and actin remodeling in neural crest cells
We utilized quantitative analyses of the proteome, transcriptome, and ubiquitinome to study how ubiquitination and NEDD4 control neural crest cell survival and stem-cell-like properties. We report 276 novel NEDD4 targets in neural crest cells and show that loss of NEDD4 leads to a striking global r...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-08 | PXD024103 | Pride
Nedd4 Ubiquitin remnant enrichment Mouse Neural crest 
ProteomicsIdentifying novel NEDD4-2 interacting proteins
NEDD4-2 is an E3 ubiquitin ligase involved in the regulation of several membrane proteins. This project was designed to identify new NEDD4-2-regulated substrates in the mouse cortical collecting duct cell line.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD063842 | Pride
Nedd4-2 
GenomicsGene expression changes in NCU10K cells lacking Nedd4
Gene expression changes in NCU10K cells lacking Nedd4
PRJNA811254 | ENA
ProteomicsIon channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
Targeted protein degradation or downregulation (TPD/TPDR) mediated by induced recruitment of an endogenous E3 ubiquitin ligase to a substrate is a disruptive paradigm for developing therapeutics. However, <2% of ~600 E3 ligases have been exploited for this modality, and efficacy for multi-subunit me...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD069051 | Pride
Hek293 cells Nedd4-2 Divalent nanobody Ion channels 
ProteomicsMouse Nedd4-2 and control with Pirfenidone
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mi...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD011119 | Pride
Pirfenidone Nedd4-2 
TranscriptomicsGene expression changes in NCU10K cells lacking Nedd4
Nedd4 is an E3 ubiquitin ligase that has essential roles in neural crest cell development. This study aimed to detect the gene expression changes induced by removing Nedd4 in the neural crest cell line, NCU10K, to define the molecular pathways regulated by Nedd4.
ORGANISM(S): Mus musculus 
2022-03-02 | GSE197631 | GEO
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