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MetabolomicsElevated lysophosphatidylcholines during SSRI-induced neural differentiation correlate with early neurodevelopmental symptoms

Background: Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy. Yet, epidemiological studies link in-utero SSRI exposure with neurodevelopmental disorders, such as autism and ADHD. The potential molecular mechanisms by which SSRIs impact early n...

2026-04-02 | MTBLS12645 | MetaboLights
TranscriptomicsRNA-seq analysis of gene expression patterns responding to TSA treatment during hESC neural differentiation
We report the differential roles of an HDAC inhibitor-TSA during hESC nerual commitment. In the initiation of hESC differentiation, TSA could inhibit the downregulation of pluripotency genes to maintain pluripotency, whereas in the neural commitment stage, TSA could promote neural gene expression to...
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-66777 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential rosette neural stem cell regulators
Rosette neural stem cells (R-NSCs) represent early stage of neural development and possess full neural differentiation and regionalization capacities. R-NSCs are considered as stem cells of neural lineage and have important implications in study of neurogenesis and cell replacement therapy. However,...
ORGANISM(S): Macaca mulatta 
2014-07-03 | E-GEOD-53260 | biostudies-arrayexpress
MetabolomicsTime-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury

Perioperative neurocognitive disorders (PND) pose a significant challenge for aging surgical patients, with sevoflurane anesthesia being an identified risk factor. Time-restricted feeding (TRF), a dietary regimen, shows promise in mitigating age-related cognitive decline, but its efficacy and mec...

2026-02-17 | MTBLS13891 | MetaboLights
TranscriptomicsJarid1b targets genes regulating development and is involved in neural differentiation [expression array]
The H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for embryonic stem cell (ESC) self-renewal, but essential for ESC differentiation along the neural lineage. During neural differentiation, Jarid1b depleted ESCs fail to efficiently silence lineage-inappropriate genes, specifically...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31967 | biostudies-arrayexpress
TranscriptomicsNotch signaling regulates neural crest differentiation from human pluripotent stem cells
The aim of the dataset was to study on genome-wide level the effect of Notch inhibition in gene expression on neural crest differentiation of human embryonic stem cells under chemically defined conditions. Total RNA from hESCs, hESC-derived neural crest, hESC-derived neural crest+DAPT, and hESC-deri...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-53203 | biostudies-arrayexpress
TranscriptomicsMediator Med23-deficiency Enhances Neural Differentiation of Embryonic Stem Cells through Modulating BMP Signaling
Unraveling the mechanisms underlying early neural differentiation of ESCs is crucial to the cell-based therapies of neurodegenerate diseases. Neural fate acquisition is proposed to be controlled by a “default” mechanism, for which the molecular regulation is not well understood. In this study, w...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-64500 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation)
We compared the gene expression profiles of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation). Cells grown in the presence of FGF-2 were used as a reference.
ORGANISM(S): Rattus norvegicus 
2006-03-15 | E-TABM-39 | biostudies-arrayexpress
TranscriptomicsNorepinephrine transporter-deficient neural crest cells
Background: The goal of this study was to determine the transcriptional consequences of norepinephrine transporter (NET) gene deletion in noradrenergic neuron differentiation. The norepinephrine transporter (NET) is the target of powerful mind-altering substances, such as tricyclic antidepressants a...
ORGANISM(S): Mus musculus 
2008-06-23 | E-GEOD-11788 | biostudies-arrayexpress
TranscriptomicsTranscription profiling during differentiation of the neural tube in HH stage 10 chick embryos
The spinal cord is generated progressively as cells leave the caudal region of the elongating body axis such that the temporal steps of neural differentiation become spatially separated along the head to tail axis. At key stages, it is therefore possible to isolate near-adjacent cell populations fro...
ORGANISM(S): Gallus gallus 
2014-08-01 | E-MTAB-2734 | biostudies-arrayexpress
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