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ProteomicsSequencing Greenlip Abalone - We have used the greenlip abalone draft genome (PRJNA433241) to generate basic genetic knowledge of the reproductive process with a specific focus on the key interactive processes of maturation, neural signalling, communication and the stress response.
We have used the greenlip abalone draft genome (PRJNA433241) to generate basic genetic knowledge of the reproductive process with a specific focus on the key interactive processes of maturation, neural signalling, communication and the stress response.
ORGANISM(S): Haliotis laevigata 
2019-07-16 | PXD009218 | Pride
Communication Exoproteins Greenlip abalone Secreted proteins Stress Neural signalling (or similar) Haliotis laevigata Reproduction 
TranscriptomicsConcerted involvement of Cdx/Hox genes and Wnt signalling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precocious expression of Hox paralogous 13 genes also induces vertebral axis truncat...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-30113 | biostudies-arrayexpress
TranscriptomicsEarly transcriptional changes linked to naturally occurring Huntington's disease mutations in human embryonic stem cells
Multiple human embryonic stem (ES) cell lines derived from blastocysts diagnosed as carrying the mutant huntingtin gene by pre-implantation diagnosis were used to explore early developmental changes in gene expression. How mutant huntingtin impacts on signalling pathways in the pre-symptomatic perio...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-34201 | biostudies-arrayexpress
TranscriptomicsWnt signalling sustains an EpiSCs subpopulation similar to primitive streak with increased mesendodermal potency
During gastrulation, epiblast cells are pluripotent and their fate is thought to be constrained principally by their position. Cell fate is progressively restricted by localised signalling cues from areas including the primitive streak (PS). However, it is unknown whether this restriction accompani...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-48476 | biostudies-arrayexpress
TranscriptomicsComparison of expression data between control and Ovo1 morphant zebrafish embryos
A fundamental issue in cell biology is how migratory cell behaviors are controlled by dynamically regulated cell adhesion. Vertebrate neural crest (NC) cells rapidly alter cadherin expression and localization at the cell surface during migration. Secreted Wnts induce some of these changes in NC adhe...
ORGANISM(S): Danio rerio 
2010-04-27 | E-GEOD-21539 | biostudies-arrayexpress
TranscriptomicsWnt signalling sustains an EpiSCs subpopulation similar to primitive streak with increased mesendodermal potency
During gastrulation, epiblast cells are pluripotent and their fate is thought to be constrained principally by their position. Cell fate is progressively restricted by localised signalling cues from areas including the primitive streak (PS). However, it is unknown whether this restriction accompanie...
ORGANISM(S): Mus musculus 
2014-03-04 | GSE48476 | GEO
TranscriptomicsCONVERGENT GENESIS OF AN ADULT NEURAL CREST-LIKE DERMAL STEM CELL FROM DISTINCT DEVELOPMENTAL ORIGINS
Skin-derived precursors (SKPs) are multipotent dermal stem cells that reside within a hair follicle niche and that share properties with embryonic neural crest precursors. Here, we have asked whether SKPs and their endogenous dermal precursors originate from the neural crest or whether, like the de...
ORGANISM(S): Rattus norvegicus 
2010-09-03 | E-GEOD-23954 | biostudies-arrayexpress
GenomicsConcerted involvement of Cdx/Hox genes and Wnt signalling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precocious expression of Hox paralogous 13 genes also induces vertebral axis truncation...
ORGANISM(S): Mus musculus 
2011-12-01 | GSE30113 | GEO
TranscriptomicsDominant Th1 and Minimal Th17 Skewing in Discoid Lupus Revealed by Transcriptomic Comparison with Psoriasis
Discoid lupus erythematosus (DLE) is the most common skin manifestation of lupus. Despite its high frequency in systemic lupus in addition to cases without extracutaneous manifestations, targeted treatments for DLE are lacking, likely because of a dearth of knowledge of the molecular landscape of DL...
ORGANISM(S): Homo sapiens 
2013-11-18 | E-GEOD-52471 | biostudies-arrayexpress
UnknownEnteric glia as a source of neural progenitors in adult zebrafish.
Not available
S-EPMC7521928 | biostudies-literature
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