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TranscriptomicsGlobal gene expression analysis of human iPSC-derived Neural Stem Cells (NSC) from LCA patients and unaffected persons
Our purpose was to investigate genes and molecular mechanisms involved in patients with Leber congenital amaurosis (LCA). Fibroblasts from two unrelated clinically-identified patients (Coriell) were reprogrammed to pluripotency by retroviral transduction. These human induced Pluripotent Stem Cells (...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-43924 | biostudies-arrayexpress
MetabolomicsLipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging (Part 3)
Not available
ORGANISM(S): Mus musculus 
ST002259 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse iPS cells from neural stem cells by 2 factors (Oct4, KLF4) (Kim, Zaehres et al.)
Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripotency and further opens up the possibility to generate patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced pluripo...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-10806 | biostudies-arrayexpress
ProteomicsQuantitative proteomics for efficient differentiation of human induced pluripotent stem cells into neural stem cells using data independent acquisition mass spectrometry.
Human induced pluripotent stem cells were differentiated into NSC for 7 days. Cells on days 0, 1, 2, 3, 5 and 7 of differentiation (2.0 × 10⁶) were washed twice with DPBS (−) and then mixed with 100 μL of dissolution buffer consisting of 12 mM sodium deoxycholate, 12 mM N-lauroylsarcosine, 100 mM Tr...
ORGANISM(S): Homo Sapiens (human) 
2022-06-27 | PXD034925 | JPOST Repository
TranscriptomicsA mechanism for the segregation of age in mammalian neural stem cells
Across life neural stem cells (NSCs) generate new neurons in the mammalian brain through asymmetric neurogenic and self-renewing cell divisions. However, the cellular mechanisms underlying NSC asymmetry remain unknown. Using fluorescence loss in photobleaching (FLIP) we here show that NSCs in vitro ...
ORGANISM(S): Mus musculus 
2015-09-22 | E-GEOD-61367 | biostudies-arrayexpress
TranscriptomicsmiRNA profiles of brain glioma stem cells and normal neural stem cells
A human microarray comprising 1658 human genome probes was used to evaluate the specific expression of miRNA between brian glioma stem cells (GSC) and normal neural stem cells(NSC). 2 total RNA samples are analyzed, brian glioma stem cells (GSC) and normal neural stem cells(NSC). cell type: brain g...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-41032 | biostudies-arrayexpress
GenomicsChIP-seq on p300, NFI and H3K27ac in mouse neural stem cells
Definition of genome wide transcriptional enhancers by overlap of p300 and H3K27ac and the role of NFI factors in the regulation of mouse neural stem cells
ORGANISM(S): Mus musculus 
2013-08-12 | E-MTAB-1423 | biostudies-arrayexpress
GenomicsTargeted DamID of selected chromatin proteins in quiescent and proliferating neural stem cells
Targeted DamID of embryonic proliferating (epNSCs), quiescent (qNSCs) and larval proliferating neural stem cells (lpNSCs) was performed using worniu-GAL4, tubGAL80ts (for qNSCs and lpNSCs condition) or worniu-GAL4 (for epNSCs condition) as a driver to express nine different Dam-fusions and Dam on it...
ORGANISM(S): Drosophila melanogaster 
2025-11-11 | E-MTAB-15696 | biostudies-arrayexpress
TranscriptomicsGeneration of parthenogenetic iPS cells from parthenogenetic neural stem cell
In pluripotential reprogramming, a pluripotent state is established within somatic cells. In this study, we have generated induced pluripotent stem (iPS) cells from bi-maternal (uniparental) parthenogenetic neural stem cells (pNSCs) by transduction with four (Oct4, Klf4, Sox2, and c-Myc) or two (Oct...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-15561 | biostudies-arrayexpress
TranscriptomicsModification of Disp3 expression levels by CRISPR/Cas9 technology affects neural stem cells capacity to differentiate.
DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. To determine the effect of DISP3 on neural stem cells phenotype of NS-5 cells, we impaired Disp3 gene using CRISPR/Cas9 technology. Modification of Disp...
ORGANISM(S): Mus musculus 
2017-02-17 | E-MTAB-4485 | biostudies-arrayexpress
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