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MetabolomicsTranscriptomics integrated with metabolomics reveals partial molecular mechanisms of nutritional risk and neurodevelopment in children with congenital heart disease

PURPOSE: To explore molecular mechanisms affecting nutritional risk and neurodevelopment in children with congenital heart disease (CHD) by combining transcriptome and metabolome analysis.

METHODS: A total of 26 blood and serum samples from 3 groups of chil...

2024-10-25 | MTBLS10118 | MetaboLights
Genomics5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging [5hmC Capture and Seq]
DNA methylation dynamics influence brain function and are altered in neurological disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base derived from 5-methylcytosine (5mC) accounts for ~40% of modified cytosine in brain, and has been implicated in DNA methylation-related plasticity. Here we map 5-h...
ORGANISM(S): Mus musculus 
2011-10-30 | E-GEOD-32050 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
UnknownGender specific influence of serotonin on core symptoms and neurodevelopment of autism spectrum disorders: A multicenter study in China.
Not available
S-EPMC11954278 | biostudies-literature
TranscriptomicsDysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders
Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for psychiatric disorders, but the molecular mechanisms that drive this association are undetermined. EHMT1 is an epigenetic repressor that is causal for Kleefstra Syndrome (KS), a neurodevelopmental disorder (NDD) lea...
ORGANISM(S): Homo sapiens 
2023-05-01 | E-MTAB-10480 | biostudies-arrayexpress
TranscriptomicsKDM5C safeguards the appropriate timing of early neurodevelopment
We generated human induced pluripotent cells from intellectual disability patients carrying the c.2T>C mutation in KDM5C (Called “Mutant”). We generated a paired, isogenic human iPS cell line (called “Corrected”) using CRISPR/Cas9 and PiggyBac gene-editing technologies and conducted neuronal differe...
ORGANISM(S): Homo sapiens 
2023-10-13 | E-MTAB-7551 | biostudies-arrayexpress
UnknownMutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.
Not available
S-EPMC12435841 | biostudies-literature
GenomicsDNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [ChIP-seq]
DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [ChIP-seq]
PRJNA622433 | ENA
GenomicsDNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [Bisulfite-Seq]
DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [Bisulfite-Seq]
PRJNA622502 | ENA
GenomicsDNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [RNA-Seq]
DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [RNA-Seq]
PRJNA621177 | ENA
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