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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsExploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors.

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
TranscriptomicsMicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines
Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-33568 | biostudies-arrayexpress
ProteomicsProteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically heterogeneous neoplasms. We used quantitative global proteomic analysis on 40 PNENs to compliment paired transcriptome data.
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD024175 | Pride
Pancreatic neuroendocrine neoplasms 
TranscriptomicsMicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines
Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important...
ORGANISM(S): Homo sapiens 
2012-11-08 | E-MTAB-862 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome
Although there has been increased knowledge about the molecular biology of neuroendocrine tumors (NETs), little is known about thymic carcinoids and even less about those with excessive hormone disorders, such as ectopic ACTH syndrome. This study was designed to gain insights into molecular networks...
ORGANISM(S): Homo sapiens 
2009-08-13 | E-GEOD-17619 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of neuroendocrine primary tumors: effect of Octreotide treatment
The management of neuroendocrine tumors (NETs) is very variable, depending on many specific aspects, such as the type of tumor, spread and patient general health. Several advances have been made with the newly developed somatostatin analogues to cure this type of malignancies. Somatostain analogues ...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-24358 | biostudies-arrayexpress
ProteomicsProteogenomic characterization of pancreatic neuroendocrine tumor
To characterize pancreatic neuroendocrine tumor at protein level, we performed mass spectromery-based proteome analysis using clinical FFPE tissue samples.
ORGANISM(S): Homo sapiens (Human) 
2024-07-10 | PXD034571 | Pride
Human Tissue Pancreatic neuroendocrine tumor 
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