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MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
TranscriptomicsLung cancer
Two prognostically significant subtypes of high-grade lung neuroendocrine tumors independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles. BACKGROUND: Classification of high-grade neuroendocrine tumors (HGNT) of the lung currently recognises large-ce...
ORGANISM(S): Homo sapiens 
2004-02-10 | E-GEOD-1037 | biostudies-arrayexpress
GenomicsASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
ChIP-Seq analysis performed on 5 ASCL1(+) cell lines and 2 ASCL1 (-) cell lines in order to understand the transcriptome of ASCL1 as it pertains to high-grade neuroendocrine lung cancers 5 ASCL1(+) lung cancer cell lines and 2 ASCL1(-) lung cancer cell lines were compared using ChIP-Seq analysis
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-61197 | biostudies-arrayexpress
TranscriptomicsNFIB is a driver of SCLC initiation, progression and metastasis in mouse and marks metastatic disease in patients
Small Cell Lung Cancer (SCLC) is the most aggressive type of lung cancer with early metastatic dissemination and invariable development of resistant disease for which no effective treatment is available to date. Mouse models of SCLC based on inactivation of Rb1 and Trp53 developed earlier showed fre...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-82005 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of lung carcinoma
Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer is not we...
ORGANISM(S): Homo sapiens 
2014-10-05 | E-GEOD-56044 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics data from the lungNENomics cohort of lung neuroendocrine tumours
This dataset contains spatial transcriptomics data of four lung neuroendocrine tumours (lung NETs), a rare and understudied type of lung cancer. The dataset consists of raw sequencing data, metadata, and gene expression matrices. It is part of the lungNENomics project. See https://doi.org/10.5281/z...
ORGANISM(S): Homo sapiens 
2026-05-22 | E-MTAB-17055 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of lung carcinoma : Gene expression data
Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. Experimental Design Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on ...
ORGANISM(S): Homo sapiens 
2014-10-05 | E-GEOD-60644 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
We sequenced mRNA from individual stormal cells (Macrophages, Monocytes, and Neutrophils) and tumor epithelial cells from KrasG12dD; p53-/- murine lung cancer model and WT control mouse to compare gene expressio profiles of lung cancer stroma and tumor cells to their counterparts of WT lugns. The tu...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-59831 | biostudies-arrayexpress
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