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TranscriptomicsNeurofibromin (Nf1) is required for skeletal muscle development
Neurofibromatosis type 1 (NF1) is a multi-system disease caused by mutations in the NF1 gene encoding a Ras-GAP protein, neurofibromin, which negatively regulates Ras signalling. Besides neuroectodermal malformations and tumours, the skeletal system is often affected (e.g. scoliosis and long bone dy...
ORGANISM(S): Mus musculus 
2011-05-18 | E-GEOD-29343 | biostudies-arrayexpress
TranscriptomicsGene profiles of pathway interference downstream neurofibromin signaling
Malignant peripheral nerve sheath tumor (MPNST) is a type of soft tissue sarcoma that occurs in carriers of mutations in the neurofibromatosis type I gene (Nf1) as well as sporadically.　Plexiform neurofibromas in NF1 patients have a significant risk of developing into MPNSTs leading to increased mor...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-GEOD-39764 | biostudies-arrayexpress
ProteomicsStructural analysis of neurofibromin by crosslinking mass spectrometry
Neurofibromin (NF1) is a fundamental inhibitor of cell growth that is conserved from yeast to humans. NF1 negatively regulates oncogenic RAS proteins by accelerating the hydrolysis of RAS-bound GTP. This activity blocks growth factor signalling upstream of both mitogen-activated protein kinase (MAPK...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD023593 | Pride
Cancer Neurofibromin Tumour-suppressor protein 
TranscriptomicsNeurofibromin (Nf1) is required for skeletal muscle development
Neurofibromatosis type 1 (NF1) is a multi-system disease caused by mutations in the NF1 gene encoding a Ras-GAP protein, neurofibromin, which negatively regulates Ras signalling. Besides neuroectodermal malformations and tumours, the skeletal system is often affected (e.g. scoliosis and long bone dy...
ORGANISM(S): Mus musculus 
2011-05-18 | GSE29343 | GEO
UnknownRestoring functional neurofibromin by protein transduction.
Not available
S-EPMC5906691 | biostudies-literature
UnknownNeurofibromin 1 regulates early developmental sleep in Drosophila.
Not available
S-EPMC10428071 | biostudies-literature
UnknownNeurofibromin and suppression of tumorigenesis: beyond the GAP.
Not available
S-EPMC9063229 | biostudies-literature
UnknownIdentification of Germinal Neurofibromin Hotspots.
Not available
S-EPMC9405573 | biostudies-literature
UnknownElucidating the impact of neurofibromatosis-1 germline mutations on neurofibromin function and dopamine-based learning.
Not available
S-EPMC4553714 | biostudies-literature
UnknownNeurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila.
Not available
S-EPMC8277851 | biostudies-literature
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