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MetabolomicsLoss of SPTSSA Impairs Mitochondrial Function and Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells
Sphingolipids are bioactive membrane and signaling lipids that not only shape cellular architecture but also orchestrate a network of interconnected metabolic pathways. Their core building blocks, sphingoid bases, are synthesized by the serine palmitoyltransferase (SPT) complex. At its core, the SPT...
2026-10-09 | MTBLS15875 | MetaboLights
TranscriptomicsRegulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis
The current study has investigated the hypothalamic gene expressions regulated by glucocorticoid (GC), key hormones in energy homeostasis. Using serial analysis of gene expression (SAGE) method, we have studied the effects of adrenalectomy (ADX) and GC on the transcriptomes of mouse hypothalamus. Ap...
ORGANISM(S): Mus musculus 
2006-09-22 | E-GEOD-3366 | biostudies-arrayexpress
UnknownRegulation of neuronal chloride homeostasis by neuromodulators.
Not available
S-EPMC4865579 | biostudies-literature
UnknownRestoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.
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S-EPMC8531145 | biostudies-literature
UnknownLocal impermeant anions establish the neuronal chloride concentration.
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S-EPMC4220679 | biostudies-literature
UnknownRestoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations.
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S-EPMC10690023 | biostudies-literature
UnknownA surge of cytosolic calcium dysregulates lysosomal function and impairs autophagy flux during cupric chloride-induced neuronal death.
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S-EPMC10750191 | biostudies-literature
UnknownTranscriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode.
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S-EPMC9232149 | biostudies-literature
UnknownHow Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.
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S-EPMC9305173 | biostudies-literature
UnknownBiophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis.
Not available
S-EPMC6200395 | biostudies-literature
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