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TranscriptomicsTranscriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
Human brain development is a complex process involving neural proliferation, differentiation, and migration which are directed by many essential cellular factors and drivers. Here, using the NetBID2 algorithm and developing human brain RNA sequencing(RNA-Seq) dataset, we identified synaptotagmin-lik...
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-10058 | biostudies-arrayexpress
TranscriptomicsImmunomagnetic purification of mES derived neuronal precursors increases neuronal migration and differentiation in vivo
All established protocols for differentiation of mouse and human pluripotent stem cells into specific neural subpopulations generate a considerable cellular heterogeneity that hampers experimental and clinical progress. In order to obtain a homogenous population of neuronal precursor cells and to st...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-35125 | biostudies-arrayexpress
TranscriptomicsWild type vs. Nova2 KO mouse E14.5 cortex RNA
To assess the requirement of Nova2 for alternative processing of RNA in the developping brain. Neuronal migration leads to a highly organized laminar structure in the mammalian brain and its mis-regulation causes lissencephaly, behavioral and cognitive defects. Reelin signaling, mediated in part by ...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-22758 | biostudies-arrayexpress
TranscriptomicsPurification of neuronal precursors from the adult mouse brain: a comprehensive gene expression analysis
The progeny of neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain consists in polysialylated NCAM-expressing immature neurons (PSA(+) cells), which migrate to the olfactory bulb (OB) to differentiate into GABAergic interneurons. We purified murine PSA(+) cells directly f...
ORGANISM(S): Mus musculus 
2007-09-21 | E-GEOD-9081 | biostudies-arrayexpress
GenomicsTubulin autoregulation mediator TTC5 regulates neuronal morphology and migration
Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration
PRJNA1375555 | ENA
TranscriptomicsExpression data from hiPSCs-NSCs towards 4T1
Neural stem cells can migrate towards tumors of both neural and non-neural origins, which is crucial for the success in treating disseminated tumors. Although the understanding of the molecular mechanisms underlying NSC tumor tropism is limited, it has been noted that several cytokines, growth facto...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-40750 | biostudies-arrayexpress
TranscriptomicsMaternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response.
Maternal immune activation is a risk factor for the development of schizophrenia and autism. Infections during pregnancy activate the mother's immune system and alter the fetal environment with sub-sequence effects of CNS function and behavior in the offspring, but the cellular and molecular links b...
ORGANISM(S): Rattus norvegicus 
2012-07-25 | E-GEOD-34058 | biostudies-arrayexpress
GenomicsTissue-wide Mechanisms Overrule Cell-intrinsic Gene Function in Radial Neuronal Migration
Tissue-wide Mechanisms Overrule Cell-intrinsic Gene Function in Radial Neuronal Migration
PRJNA825516 | ENA
GenomicsTranscriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
PRJEB42753 | ENA
GenomicsExpanded Neuronal Migration Supports Region-specific Distribution of Inhibitory Neurons in the Gyrencephalic Brain
Expanded Neuronal Migration Supports Region-specific Distribution of Inhibitory Neurons in the Gyrencephalic Brain
PRJNA1077320 | ENA
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