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GenomicsNeuronal identity defines a-synuclein and tau toxicity
Neuronal identity defines a-synuclein and tau toxicity
PRJNA926993 | ENA
GenomicsCircadian clock-mediated neuronal gene expression in Aβ toxicity and excitotoxicity
Circadian clock-mediated neuronal gene expression in Aβ toxicity and excitotoxicity
PRJNA849149 | ENA
TranscriptomicsDistinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases
Dominantly inherited expanded repeat neurodegenerative diseases are typically caused by the expansion of existing variable copy number tandem repeat sequences in otherwise unrelated genes. Repeats located in translated regions encode polyglutamine that is thought to be the toxic agent, however in se...
ORGANISM(S): Drosophila melanogaster 
2013-04-05 | E-GEOD-42910 | biostudies-arrayexpress
TranscriptomicsNeuronal identity defines a-synuclein and tau toxicity
Pathogenic a-synuclein and tau are critical drivers of neurodegeneration and their mutations cause neuronal loss in patients. Whether the underlying preferential neuronal vulnerability is a cell-type intrinsic property or a consequence of increased expression levels remains elusive. Here, we explore...
ORGANISM(S): Drosophila melanogaster 
2023-03-21 | GSE223626 | GEO
ProteomicsRepeat length of the C9orf72-associated glycine-alanine polypeptides affects their toxicity
G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G4C2 insertion length is variable, and patients can carry up to several thousand repeats. Dipeptide repeat pro...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-12 | PXD038900 | Pride
Toxicity Repeat length Drosophila C9orf72 Glycine-alanine 
UnknownNeuronal identity defines α-synuclein and tau toxicity.
Not available
S-EPMC10191620 | biostudies-literature
GenomicsGenome-wide in vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity
Genome-wide in vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity
PRJNA594969 | ENA
UnknownAmyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity.
Not available
S-EPMC6614131 | biostudies-literature
GenomicsShortening the half-life of Cas9 maintains its gene editing ability and reduces neuronal toxicity
Shortening the half-life of Cas9 maintains its gene editing ability and reduces neuronal toxicity
PRJNA503401 | ENA
UnknownAxon degeneration is key component of neuronal death in amyloid-β toxicity.
Not available
S-EPMC3918889 | biostudies-literature
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