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MetabolomicsMetabolome analysis via an HPLC-ESI-MS-based experimental and computational pipeline for chronic nephron toxicity profiling
Untargeted metabolomics has the potential to improve the predictivity of in vitro toxicity models and therefore may aid the reduction of expensive and laborious animal models. Here we describe a chronic nephrotoxicity study conducted on a human renal proximal tubular epithelial cell line (RPTEC/TERT...
2015-09-07 | MTBLS140 | MetaboLights
MetabolomicsMulti-omics toxicity profiling of engineered nanomaterials

This study aims to implement methods for toxicological profiling of engineered nanomaterials using toxicogenomics, proteomics, and metabolomics along with computational analyses. For all three omics layers the human cell lines A549 (lung epithelial cells) and THP1 (monocytes) were separately expo...

2016-12-05 | MTBLS277 | MetaboLights
MetabolomicsA multiomic approach to reveal gastrointestinal toxicity mechanisms associated with mycophenolate mofetil in neuromyelitis optica spectrum disorders
Mycophenolate mofetil (MMF) has been widely prescribed for neuromyelitis optica spectrum disorders (NMOSD) although some patients experience severe gastrointestinal (GI) side effects following MMF administration. Our study investigated the potential mechanisms of this toxicity in NMOSD patients. We ...
2024-06-18 | MTBLS4392 | MetaboLights
MetabolomicsIntegration of metabolomics and transcriptome reveals toxicity variations of Alternaria
Alternaria, a widespread fungal genus, infects a wide range of crops and produces various toxins, such as Tentoxin (TEN), Tenuazonic acid (TeA), Alternariol (AOH) during infection, leading to a major concern about safety of these crops. Although the toxin-producing ability varies among different Alt...
2024-09-26 | MTBLS6073 | MetaboLights
MetabolomicsInvestigating the Mechanisms of Silver Nanoparticle Toxicity in Daphnia magna: A Multi-Omics Approach
Silver nanoparticles (AgNPs), one of the most common nanomaterials in use today, have been shown to enter the aquatic environment from use of commercially obtained products. Although acute toxicity has been shown in vitro and in vivo, there is still a great deal of uncertainty surrounding the molecu...
2017-05-08 | MTBLS260 | MetaboLights
MetabolomicsA targeted metabolomics study for assessing rodent thyroid toxicity
Not available
ORGANISM(S): Rattus norvegicus 
ST002023 | MetabolomicsWorkbench
MetabolomicsMulti-omics profiling identifies MAPK signaling suppression associated with tetracycline-induced root toxicity in soybean
Tetracycline (TC), a widely used veterinary antibiotic, is a pervasive emerging contaminant threatening crop production. Here, we employed integrated physiological, metabolomic, and transcriptomic analyses to decipher the response of soybean (Glycine max L.) to TC. While seed germination was unaffec...
2026-09-07 | MTBLS15077 | MetaboLights
MetabolomicsZebrafish Metabolomics: Model for Environmental Metal Toxicity
Not available
ORGANISM(S): Danio rerio 
ST000365 | MetabolomicsWorkbench
MetabolomicsAnalyzing nicotine action against amyloid toxicity by NMR-pharmacometabolomics: an exploratory study

Alzheimer's disease (AD) is the primary neurodegenerative disease spread worldwide. One of the main histopathological hallmarks of AD is amyloid plaque deposition in the brain. Despite some epidemiological studies demonstrating that cigarette smoke is a factor in predisposing people to AD, nicoti...

2026-06-26 | MTBLS12706 | MetaboLights
MetabolomicsMechanism of Trichloroethylene (TCE) toxicity in the placenta
Not available
ORGANISM(S): Homo sapiens 
ST001398 | MetabolomicsWorkbench
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