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MetabolomicsMetabolome profiling by untargeted metabolomics and biomarker panel selection using machine-learning for patients in different stages of peripheral neuropathy induced by oxaliplatin

Background: Oxaliplatin-induced peripheral neuropathy (OIPN) poses a significant challenge for patients with colorectal tumor, often resulting in treatment interruption or discontinuation and subsequent treatment failure. Herein, a longitudinal untargeted metabolomic study to reveal the metabolom...

2025-08-14 | MTBLS12854 | MetaboLights
MetabolomicsMicrobial-derived Hyodeoxycholic Acid Ameliorates Painful Diabetic Neuropathy by Modulating Dorsal Root Ganglion TLR4-Mediated Neuroinflammation Signaling Pathway

BACKGROUND: Painful diabetic neuropathy (PDN) is characterized by hyperalgesia and neuronal hyperexcitability. Although gut microbiota dysbiosis have been found in PDN, how microbiota influences PDN remains largely unexplored. RESULTS: Gut microbiota and its metabolites impacted PDN was investiga...

2026-08-24 | MTBLS12087 | MetaboLights
MetabolomicsMitochondrial Lipid Profiles in Traumatic Optic Neuropathy
Not available
ORGANISM(S): Mus musculus 
ST001327 | MetabolomicsWorkbench
MetabolomicsEffect of high fat diet and streptozotocin treatment on neuropathy
Not available
ORGANISM(S): Mus musculus 
ST000676 | MetabolomicsWorkbench
MetabolomicsMetabolomics study in Plasma of Obese Patients with Neuropathy Identifies Potential Metabolomics Signatures
Not available
ORGANISM(S): Homo sapiens 
ST001412 | MetabolomicsWorkbench
MetabolomicsHuman serum for a patient with neuropathy being treated with L-serine.
Not available
ORGANISM(S): Homo sapiens 
ST000876 | MetabolomicsWorkbench
MetabolomicsLipidomics Dataset of Sonication-Induced Traumatic Optic Neuropathy in Mice
Not available
ORGANISM(S): Mus musculus 
ST001273 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
A study of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
ORGANISM(S): Rattus norvegicus 
2006-12-10 | E-MEXP-515 | biostudies-arrayexpress
TranscriptomicsExpression data from a Charcot-Marie-Tooth 1B neuropathy mouse model
We have generated mouse models of real CMT1B mutations in the gene encoding for myelin protein zero (P0). One of these mutants, P0S63del is retained in the ER where it elicits an unfolded protein response (UPR). Genetic ablation of the UPR factor CHOP restores the motor capacity in S63del mice. We u...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-40610 | biostudies-arrayexpress
TranscriptomicsSILENCING OF PNPLA6, THE NEUROPATHY TARGET ESTERASE (NTE) CODIFYING GENE, ALTERS HUMAN NEURODIFFERENTIATION IN VITRO
Neuropathy Target Esterase (NTE) is a protein involved in the development of a polyneuropathy caused by exposure to certain organophosphorus compounds. In vivo and in vitro studies have also associated NTE with embryonic development since NTE null mice embryos are non-viable, and silencing the NTE-c...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-55761 | biostudies-arrayexpress
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