Sort   by:  
 Page size 
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
MetabolomicsNeuropeptide SP protects against colitis and linked anxiety-like behavior via gut microbiota and metabolite inositol: A multi-omics analysis of the gut-brain axis

The gut-brain axis facilitates two-way communication between gut inflammation and psychiatric comorbidities associated with inflammatory bowel disease (IBD). In this study, we examined the neuroprotective effects of the neuropeptide substance P (SP) on colitis. Taking into account the interaction...

2025-11-18 | MTBLS11203 | MetaboLights
ProteomicsMass spectrometric evidence for neuropeptide-amidating enzymes in C. elegans
Neuropeptides constitute a vast and functionally diverse family of neurochemical signaling molecules, and are widely involved in the regulation of various physiological processes. The nematode C. elegans is well-suited for the study of neuropeptide biochemistry and function, as neuropeptide biosynth...
ORGANISM(S): Caenorhabditis elegans 
2018-03-12 | PXD008942 | Pride
Peptidomics  mass spectrometry  neuropeptide  amidation  copper monooxygenase  phm  pal  pam  caenorhabditis elegans  lc-orbitrap ms 
ProteomicsMultifaceted Mass Spectrometric Investigation of Neuropeptide Changes in Atlantic Blue Crab, Callinectes sapidus, in Response to Low pH Stress
The decrease of pH level in the water affects animals living in aquatic habitat, such as crustaceans. The molecular mechanisms enabling these animals to survive this environmental stress remain unknown. To understand the modulatory function of neuropeptides in crustaceans when encountering drops in ...
ORGANISM(S): Crustacea 
2021-09-08 | PXD013536 | Pride
Mass spectrometry Neuropeptide Crustacean 
TranscriptomicsTranscription profiling of Neuropeptide S Receptor 1-A (NPSR1-A) transfected human epithelial kidney cells stimulated with neuropeptide S to identify downstream targets
The purpose of this study was to identify downstream gene targets regulated by Neuropeptide S Receptor 1 (NPSR1) upon NPS stimulation. To do this we used human epithelial kidney (HEK)-293H cell lines stable transfected with NPSR1-A and stimulated with NPS for 6 hours. Two controls were used: NPS sti...
ORGANISM(S): Homo sapiens 
2006-08-24 | E-MEXP-829 | biostudies-arrayexpress
ProteomicsA neuropeptide regulates cell non-autonomous protein homeostasis
The coordination of protein homeostasis from the brain to periphery is essential for the health and survival of all animals. In C. elegans, glia serve a central role in coordinating organismal protein homeostasis and longevity via the unfolded protein response of the endoplasmic reticulum (UPRER). H...
ORGANISM(S): Caenorhabditis elegans 
2026-03-09 | PXD062951 | Pride
Neuropeptide C. elegans Upr Proteostasis 
ProteomicsExploring the Sexual Dimorphism of Crustacean Neuropeptide Expression using Callinectus sapidus as a Model Organism
The impact of numerous diseases has been linked to differences in sex between organisms, including various neurological diseases. As neuropeptides are known to be key players in the nervous system, studying the variation of neuropeptidomic profiles between males and females in a crustacean model org...
ORGANISM(S): Callinectes Sapidus (ncbitaxon:6763) 
2020-07-05 | MSV000085694 | MassIVE
ProteomicsNeuropeptide inactivation regulates egg-laying behavior to influence reproductive health in Caenorhabditis elegans
Neural communication requires both fast-acting neurotransmitters and neuromodulators that function on slower timescales to communicate. Endogenous bioactive peptides, often called “neuropeptides,” comprise the largest and most diverse class of neuromodulators that mediate crosstalk between the brain...
ORGANISM(S): Caenorhabditis elegans 
2024-10-11 | PXD050464 | Pride
Neuropeptidase Neuropeptide Healthspan C. elegans Aging Behavior Neural circuit 
TranscriptomicsSynaptic activity-regulated gene expression_embryonic day 18
Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null ...
ORGANISM(S): Mus musculus 
2006-07-31 | E-GEOD-3639 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in ahr-1 mutants compared to wild-type C. elegans
The aryl hydrocarbon receptor (AHR) functions in higher organisims in development, metabolism and toxic responses. Its Caenorhabditis elegans (C. elegans) ortholog, AHR-1, facilitates neuronal development, growth and movement. We investigated the effect of AHR mutation on the transcriptional profile...
ORGANISM(S): Caenorhabditis elegans 
2014-09-19 | E-GEOD-61537 | biostudies-arrayexpress
Sort   by:  
 Page size