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GenomicsSmall Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons
Small Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons
PRJNA896539 | ENA
TranscriptomicsEffect of small molecules on activated astrocytes
We have developed an assay to test the neuroprotective properties of compounds using stem cellM-bM-^@M-^Sderived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated astrocytes cells was test...
ORGANISM(S): Mus musculus 
2012-11-03 | E-GEOD-37611 | biostudies-arrayexpress
TranscriptomicsEffect of small molecules on activated BV2 microglia cell line
We have developed an assay to test the neuroprotective properties of compounds using stem cellM-bM-^@M-^Sderived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated BV2 cells was tested. The...
ORGANISM(S): Mus musculus 
2012-11-03 | E-GEOD-37612 | biostudies-arrayexpress
GenomicsEUREMAP Demonstrator Project: Small Molecules in Marine Opisthobranchs for the Development of Novel Drugs (3958)
EUREMAP Demonstrator Project: Small Molecules in Marine Opisthobranchs for the Development of Novel Drugs (3958)
PRJEB111370 | ENA
UnknownDevelopment of proneurogenic, neuroprotective small molecules.
Not available
S-EPMC3033481 | biostudies-literature
GenomicsSmall Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons
MicroRNAs (miRNAs) are short RNAs that regulate fundamental biological processes. miR-132, a key miRNA with established functions in Tau homeostasis and neuroprotection, is consistently downregulated in Alzheimer’s disease (AD) and other tauopathies. miR-132 overexpression rescues neurodegenerative ...
ORGANISM(S): Homo sapiens 
2023-10-19 | GSE216991 | GEO
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
TranscriptomicsEffect of small molecules on activated astrocytes
We have developed an assay to test the neuroprotective properties of compounds using stem cell–derived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated astrocytes cells was tested.
ORGANISM(S): Mus musculus 
2012-11-03 | GSE37611 | GEO
UnknownIdentification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.
Not available
S-EPMC3280078 | biostudies-literature
TranscriptomicsEffect of small molecules on activated BV2 microglia cell line
We have developed an assay to test the neuroprotective properties of compounds using stem cell–derived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated BV2 cells was tested.
ORGANISM(S): Mus musculus 
2012-11-03 | GSE37612 | GEO
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