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TranscriptomicsNeurotrophin NT3 promotes ovarian primordial to primary follicle transition
Neurotrophins are growth factors that are known to have a role in promoting cell survival and differentiation. The focus of the current study is to examine the role of neurotrophins in regulating ovarian primordial follicle development. Ovaries from 4-day old rats were placed into organ culture and ...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20358 | biostudies-arrayexpress
TranscriptomicsEffect of neurotrophin p75 receptor (p75NTR) on angiogenesis
Neurotrophins (NTs) promotes angiogenesis and EC survival, via tropomyosin kinase trkA and trkB receptors. A different p75NTR receptor of NTs, which belongs to the TNF-alfa receptor superfamily, is not or scarcely expressed by endothelial cells (EC) and endothelial progenitor cells (EPC) under basal...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-9910 | biostudies-arrayexpress
TranscriptomicsAnalysis of human neurotrophins and receptors in bone marrow stromal cells (BMSC) treated with NGF or BDNF
BMSC gene expression profiling was completed to examine the baseline neurotrophin and receptor gene expression in BMSC and to evaulate changes in gene expression in response to NGF or BDNF stimulation In the study, primary BMSC were treated with recombinant human NGF or BDNF for 24 hours. Following...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-18537 | biostudies-arrayexpress
TranscriptomicsExpression data from neurotrophin transgenic mice
A limited number of growth factors are capable of regulating numerous developmental processes, but how they accomplish this is unclear. In the gustatory system, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) have different developmental roles but exert their effects through the sa...
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-44734 | biostudies-arrayexpress
ProteomicsPTPN23 is required for endocytic sorting of neurotrophin receptors via a BICD1- dependent mechanism
Signalling by target-derived neurotrophins is essential for the correct development of the nervous system and its maintenance throughout life. Several aspects concerning the lifecycle of neurotrophins and their receptors, tropomyosin receptor kinases (Trks) and p75NTR, have been characterised over t...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD016190 | Pride
Interaction proteomics Maxquant Ibaq Gelc-ms 
TranscriptomicsAltered neurotrophin expression profiles in the nucleus of the solitary tract of spontaneously hypertensive rats
Our previous findings suggest that the nucleus of the solitary tract (NTS), a pivotal region for regulating the set-point of arterial pressure, exhibits abnormal inflammation in pre-hypertensive and spontaneously hypertensive rats (SHRs) together with elevated anti-apoptotic and low apoptotic factor...
ORGANISM(S): Rattus norvegicus 
2015-04-15 | E-GEOD-67874 | biostudies-arrayexpress
GenomicsNeurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial differentiation
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial differentiation
PRJNA852562 | ENA
TranscriptomicsNeurotrophin NT3 promotes ovarian primordial to primary follicle transition
Neurotrophins are growth factors that are known to have a role in promoting cell survival and differentiation. The focus of the current study is to examine the role of neurotrophins in regulating ovarian primordial follicle development. Ovaries from 4-day old rats were placed into organ culture and ...
ORGANISM(S): Rattus norvegicus 
2010-02-16 | GSE20358 | GEO
UnknownNuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding.
Not available
S-EPMC6726010 | biostudies-literature
TranscriptomicsChanges in mRNA in the dorsal root ganglion after CNS injury and intramuscular neurotrophin-3 treatment
Brain and spinal injury often impair sensorimotor processing in the spinal cord and reduce mobility. We established that complete transection of corticospinal pathways in the pyramids leads to increased spasms, excessive mono- and polysynaptic spinal reflexes and impaired locomotion in rats. Intramu...
ORGANISM(S): Rattus norvegicus 
2018-05-29 | GSE82195 | GEO
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