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MetabolomicsFungus Rhizopus microsporus var. rhizopodiformis Promotes Hepatic Steatosis via Upregulation of Hepatic Neutrophil Degranulation

Objective:

Metabolic associated fatty liver disease (MAFLD) affects approximately 25% of the global population, posing a serious threat to public health, and its pathogenesis remains largely unknown. Gut fungi play a significant role in the development of liver diseases, but the gut microbi...

2025-12-01 | MTBLS13120 | MetaboLights
MetabolomicsAlistipes putredinis Alleviates Metabolic-Associated Fatty Liver Disease via the Acetate-GPR43 Axis by Suppressing Neutrophil ROS Generation

Background & Aims:

Intestinal dysbiosis contributes to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), though precise bacterial targets and mechanisms remain incompletely elucidated. This study investigated whether the depletion of Alistipes putredinis (AP) in adol...

2026-01-15 | MTBLS13694 | MetaboLights
MetabolomicsAlistipes putredinis Alleviates Metabolic-Associated Fatty Liver Disease via the Acetate-GPR43 Axis by Suppressing Neutrophil ROS Generation

Background & Aims:

Intestinal dysbiosis contributes to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), though precise bacterial targets and mechanisms remain incompletely elucidated. This study investigated whether the depletion of Alistipes putredinis (AP) in adol...

2026-01-15 | MTBLS13691 | MetaboLights
MetabolomicsHistidine improves Hashimoto thyroiditis by inhibiting the production of Neutrophil Txtracellular Traps

Objective: Metabolite abnormalities are potentially implicated in pathogenesis of Hashimoto’s thyroiditis (HT). An in-depth study of the relationship between HT and small molecule metabolites, as well as its pathogenesis, can help enhance the diagnosis, prognosis, and treatment of HT patients.

2025-10-12 | MTBLS12333 | MetaboLights
MetabolomicsFungus Rhizopus microsporus var. rhizopodiformis Promotes Hepatic Steatosis via Upregulation of Hepatic Neutrophil Degranulation

Objective:

Metabolic associated fatty liver disease (MAFLD) affects approximately 25% of the global population, posing a serious threat to public health, and its pathogenesis remains largely unknown. Gut fungi play a significant role in the development of liver diseases, but the gut microbi...

2026-01-17 | MTBLS13705 | MetaboLights
MetabolomicsAlistipes putredinis Alleviates Metabolic-Associated Fatty Liver Disease via the Acetate-GPR43 Axis by Suppressing Neutrophil ROS Generation

Background & Aims:

Intestinal dysbiosis contributes to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), though precise bacterial targets and mechanisms remain incompletely elucidated. This study investigated whether the depletion of Alistipes putredinis (AP) in adol...

2026-01-16 | MTBLS13699 | MetaboLights
TranscriptomicsTranscription profiling of human CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation
analysis of differential gene expression in CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation
ORGANISM(S): Homo sapiens 
2009-08-14 | E-TABM-754 | biostudies-arrayexpress
TranscriptomicsExpression data from control, aged and activated neutrophils in mouse blood
Neutrophils provide immune protection against pathogens but also may promote tissue injury in inflammatory diseases. Although neutrophils are generally considered as a relatively homogeneous population, evidence for heterogeneity is emerging. Under steady-state conditions, neutrophil heterogeneity m...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-69886 | biostudies-arrayexpress
ProteomicsDynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming
Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear bloo...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD013785 | Pride
Transcriptomics Proteomics Neutriphils Myeloid differentiation 
ProteomicsProteome analysis of human neutrophil granulocytes from patients with monogenic disease using data-independent acquisition
Neutrophil granulocytes are critical mediators of innate immunity and tissue regeneration. Rare diseases of neutrophil granulocytes may affect their differentiation and/or functions. However, there are very few validated diagnostic tests assessing the functions of neutrophil granulocytes in these ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-01 | PXD010701 | Pride
Primary immunodeficiency diseases Proteomics Whole exome sequencing Rare disease Systems medicine Multi-omics analysis Neutrophil granulocyte 
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