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ProteomicsCharacterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
Neutrophils have an important role in rapid antimicrobial defenses against and resolution of urinary tract infections (UTIs). We show that a mechanism known as neutrophil extracellular trap (NET) formation is a strategy to combat pathogens in the urinary tract. Viscous aggregates that were present i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080847 | MassIVE
TranscriptomicsCritical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes.
Abstract
BACKGROUND: Gene expression profiling (GEP) in cells obtained from peripheral blood has demonstrated to be a very useful approach for biomarker discovery and for studying molecular pathogenesis of prevalent diseases. While there is limited literature availble on gene expression markers a...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-MEXP-3589 | biostudies-arrayexpress
TranscriptomicsNeutrophil-derived pro-inflammatory cytokine response and degranulation in function of time and dose of LPS treatment.
The purpose of the present study was to elucidate in more details the molecular mechanisms of neutrophil-mediated inflammation. We therefore investigated the time-dependent stimulatory potential of LPS from Escherichia coli on cytokine response in neutrophil-like HL-60 cells.

To get a genera...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-MTAB-1393 | biostudies-arrayexpress
ProteomicsThe Miniaturized Isolation of Neutrophil Granules (MING) method allowed a deep proteome mapping of human neutrophil granules
Search files, Raw mass spectrum files in a non-standard (.raw) and standardized format (.mzML) for shotgun proteomics of the neutrophil granules using the MING method.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-24 | MSV000095691 | MassIVE
ProteomicsThe Miniaturized Isolation of Neutrophil Granules (MING) method
Raw mass spectrum files for shotgun proteomics of the neutrophil granules using the MING method. NOT THE FINAL DATASET. VIEW MSV000095691
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-23 | MSV000095690 | MassIVE
TranscriptomicsMiRNA expression profiling in bone-marrow-derived neutrophils of lcn2 deficient mouse
Lipocalin 24p3 (24p3) is a neutrophil secondary granule protein. 24p3 is also a siderocalin, which binds several bacterial siderophores. It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden sid...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43890 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in bone-marrow-derived neutrophils of lcn2 deficient mouse
Lipocalin 24p3 (24p3) is a neutrophil secondary granule protein. 24p3 is also a siderocalin, which binds several bacterial siderophores. It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden sid...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43889 | biostudies-arrayexpress
ProteomicsSpatiotemporal glycoproteome remodelling in neutrophils
Neutrophils are short-lived yet vital innate immune cells equipped with bioactive glycoproteins packed in cytosolic granules that can readily be mobilised to elicit an effective and timely response against invading pathogens. Since the dynamic glycosylation processes underpinning the dramatic metamo...
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD039387 | Pride
Remodelling Neutrophil Glycoproteomics Maturation Granule Glycoproteome 
TranscriptomicsTracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: a Link Between Stalled Polyribosomes and RNA Granules
Local translation at the synapse plays key roles in neuron development and activity-dependent synaptic plasticity. mRNAs are translocated from the neuronal soma to the distant synapses as compacted ribonucleoparticles referred to as RNA granules. These contain many RNA-binding proteins, including th...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-83835 | biostudies-arrayexpress
ProteomicsRadiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization
Radiotherapy, a treatment modality received by more than half of all cancer patients, remains one of the most effective approaches to achieve local tumour control. Despite increased accuracy driven by technological advances, healthy tissue injury due to off-target radiation exposure can still occur...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-13 | PXD027628 | Pride
Cancer Neutrophil granules Radiotherapy Metastasis 
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