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ProteomicsProteome analysis of human neutrophil granulocytes from patients with monogenic disease using data-independent acquisition
Neutrophil granulocytes are critical mediators of innate immunity and tissue regeneration. Rare diseases of neutrophil granulocytes may affect their differentiation and/or functions. However, there are very few validated diagnostic tests assessing the functions of neutrophil granulocytes in these ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-01 | PXD010701 | Pride
Primary immunodeficiency diseases Proteomics Whole exome sequencing Rare disease Systems medicine Multi-omics analysis Neutrophil granulocyte 
TranscriptomicsChanges in gene expression of granulocytes during in vivo G-CSF/dexamethasone mobilization.
Treatment of healthy donors with G-CSF and dexamethasone, results in sufficient number of circulating granulocytes to prepare granulocyte concentrates for clinical purposes. Granulocytes obtained this way demonstrate relatively normal functional behavior combined with a prolonged life span. To study...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-12841 | biostudies-arrayexpress
GenomicsRNAseq of unstimulated human neutrophil granulocytes.
RNAseq of unstimulated human neutrophil granulocytes.
PRJNA486331 | ENA
ProteomicsCD177 deficiency defines a stable subtype of human neutrophil granulocytes
CD177 is a surface protein on human neutrophil granulocytes whose function is related, but not limited to, tissue infiltration. While a fraction of the population is completely CD177-deficient (CD177d), most individuals express CD177. Expression levels on cells are not uniform and in every individua...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD068607 | Pride
Human neutrophils Proteomics Circulation Inflammation Lfq Cd177 
GenomicsIndoleamine 2,3-dioxygenase cannot inhibit Chlamydia trachomatis growth in HL-60 human neutrophil granulocytes
Indoleamine 2,3-dioxygenase cannot inhibit Chlamydia trachomatis growth in HL-60 human neutrophil granulocytes
PRJNA747175 | ENA
TranscriptomicsNeutrophil-derived pro-inflammatory cytokine response and degranulation in function of time and dose of LPS treatment.
The purpose of the present study was to elucidate in more details the molecular mechanisms of neutrophil-mediated inflammation. We therefore investigated the time-dependent stimulatory potential of LPS from Escherichia coli on cytokine response in neutrophil-like HL-60 cells.

To get a genera...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-MTAB-1393 | biostudies-arrayexpress
TranscriptomicsHuman lupus netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules
Our group has proposed that low-density granulocytes (LDGs) play an important role in lupus pathogenesis, as they can damage endothelial cells and synthesize increased levels of proinflammatory cytokines and type I interferons. LDGs have a heightened capacity to synthesize neutrophil extracellular t...
ORGANISM(S): Homo sapiens 
2011-06-22 | E-GEOD-26975 | biostudies-arrayexpress
ProteomicsDynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming
Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear bloo...
ORGANISM(S): Homo sapiens (Human) 
2019-11-07 | PXD013785 | Pride
Transcriptomics Proteomics Neutriphils Myeloid differentiation 
TranscriptomicsIndoleamine 2,3-dioxygenase cannot inhibit Chlamydia trachomatis growth in HL-60 human neutrophil granulocytes
Neutrophil granulocytes are the major cells involved in the Chlamydia trachomatis (C.trachomatis)-mediated inflammation and histopathology. A key gene in human intracellular antichlamydial defense is the tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO), which limits the growth of the tr...
ORGANISM(S): Homo sapiens 
2021-11-08 | GSE180238 | GEO
UnknownCharacteristics of quantum dots phagocytosis by neutrophil granulocytes.
Not available
S-EPMC6441825 | biostudies-literature
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