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ProteomicsCDC-like Kinase 4 Deficiency Contributes to Pathological Cardiac Hypertrophy by Modulating NEXN Phosphorylation
Kinase-catalyzed phosphorylation plays crucial roles in numerous biological processes. CDC-like kinases (CLKs) are a group of evolutionarily conserved dual-specificity kinases that have been implicated in RNA splicing, glucose metabolism, diet-induced thermogenesis and so on. However, it is still la...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-05 | PXD029682 | Pride
Pathologic cardiac hypertrophy Cdc-like kinase 4 Phosphorylation Nexn 
GenomicsNEXN regulates vascular smooth muscle cells phenotypic switching and neointimal hyperplasia
NEXN regulates vascular smooth muscle cells phenotypic switching and neointimal hyperplasia
PRJNA1262900 | ENA
GenomicsNEXN protects against vascular calcification by promoting SERCA2 SUMOy-lation and stabilization
NEXN protects against vascular calcification by promoting SERCA2 SUMOy-lation and stabilization
PRJNA1265212 | ENA
UnknownLong noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN.
Not available
S-EPMC6391138 | biostudies-literature
GenomicsCDC-like Kinase 4 Deficiency Contributes to Pathological Cardiac Hypertrophy by Modulating NEXN Phosphorylation
CDC-like Kinase 4 Deficiency Contributes to Pathological Cardiac Hypertrophy by Modulating NEXN Phosphorylation
PRJNA782453 | ENA
TranscriptomicsNEXN regulates vascular smooth muscle cells phenotypic switching and neointimal hyperplasia
Vascular smooth muscle cells (VSMCs) exhibit significant heterogeneity and plasticity, enabling them to switch between contractile and synthetic states, which is crucial for vascular remodeling. NEXN has been identified as a high confidence gene associated with dilated cardiomyopathy (DCM). Existing...
ORGANISM(S): Homo sapiens 
2025-05-16 | GSE297149 | GEO
GenomicsNEXN deficiency leads to dilated cardiomyopathy in human pluripotent stem cell-derived cardiomyocytes
NEXN deficiency leads to dilated cardiomyopathy in human pluripotent stem cell-derived cardiomyocytes
PRJNA1191047 | ENA
TranscriptomicsNEXN protects against vascular calcification by promoting SERCA2 SUMOy-lation and stabilization
Vascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells (VSMCs) from a contractile to an osteogenic phenotype. NEXN, a protein highly associated with heart function, has also been implicated as a potential suscepti...
ORGANISM(S): Homo sapiens 
2025-06-04 | GSE297578 | GEO
TranscriptomicsCDC-like Kinase 4 Deficiency Contributes to Pathological Cardiac Hypertrophy by Modulating NEXN Phosphorylation
To investigate how sustained NEXN phosphorylation ameliorated the pathological phenotype in Clk4-cKO mice. We performed microarray analysis in the Clk4-cKO myocardium treated with AAV NEXN-S437E, wherein AAV NEXN-WT served as a control.
ORGANISM(S): Mus musculus 
2021-11-23 | GSE188360 | GEO
UnknownNEXN regulates vascular smooth muscle cell phenotypic switching and neointimal hyperplasia.
Not available
S-EPMC12288906 | biostudies-literature
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