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TranscriptomicsTranscription profiling of rat pancreatic beta-cells in response to cytokine exposure and NF-kappa B activation blocking
Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic beta-cells. Based on findings suggesting NF-kappa B plays a role in beta cell apoptosis, we blocked NF-kappa B activation in cytokine-exposed FACS sorted beta cells by a recombinant adenovirus (AdI kappa B((SA)2)) containi...
ORGANISM(S): Rattus norvegicus 
2006-06-16 | E-CBIL-9 | biostudies-arrayexpress
GenomicsThe NF-kB genomic landscape in lymphoblastoid B-cells
The nuclear factor kB (NF-kB) subunits RelA, RelB, c-Rel, p50 and p52 are each critical for B-cell development and function. To systematically characterize their responses to canonical and non-canonical NF-kB pathways activity, we performed ChIP-seq analysis in lymphoblastoid B-cells. We found a su...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-55105 | biostudies-arrayexpress
Transcriptomicsp100 deficiency alone is insufficient for full activation of the alternative NF-?B pathway: TNF signaling cooperates with p52-RelB activation in the transcriptional regulation of the enpp2/autotaxin promoter
Background: Constitutive activation of the alternative NF-?B pathway leads to marginal zone B cell expansion and disorganized spleen microarchitecture. Furthermore, uncontrolled alternative NF-?B signaling results in the development and progression of cancer. We aimed here to learn about the mechani...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-30317 | biostudies-arrayexpress
TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
TranscriptomicsIdentification of LMX1B target genes in a tet-off inducible HeLa cell line and in the mouse kidney
LMX1B is a LIM-homeodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies; however, in the absence of in vivo molecular characterization of their regulation, their identity as direct LMX1B targets remains hypothet...
ORGANISM(S): Homo sapiens 
2008-12-03 | E-GEOD-12008 | biostudies-arrayexpress
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
GenomicsConcurrent activation of NF-kB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion
Concurrent activation of NF-kB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion
PRJNA480696 | ENA
TranscriptomicsExpression of ZAP-70 in CLL activates NF-M-NM-:B signaling
Chronic lymphocytic leukemia (CLL) is a disease with a highly variable prognosis. The clinical course can however be predicted thanks to prognostic markers. Poor prognosis is associated with expression of a B cell receptor (BCR) from unmutated immunoglobulin variable heavy-chain genes (IgVH) and exp...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-51286 | biostudies-arrayexpress
GenomicsCoactivation of NF-kB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion
Coactivation of NF-kB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion
PRJNA562513 | ENA
TranscriptomicsCompensatory IKKa activation of classical NF-kB signaling during IKKb inhibition
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive NF-kB pathway signaling for survival. Small molecule inhibitors of IkB kinase b (IKKb), a key regulator of the NF-kB pathway, kill ABC DLBCL cells and hold promise for the treatment ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11902 | biostudies-arrayexpress
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