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TranscriptomicsChromatin immunoprecipitation of human cells after lipopolysaccharide stimulation, to identify binding of NF-KappaB family members
The NF-KappaB family of transcription factors plays a critical role in numerous cellular processes, particularly the immune response. Our understanding of how the different NF-kappaB subunits act coordinately to regulate gene expression is based on a limited set of genes. We used genome-scale locati...
ORGANISM(S): Homo sapiens 
2006-05-09 | E-WMIT-6 | biostudies-arrayexpress
TranscriptomicsPU.1 and C/EBPalpha synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers (expression data)
Unraveling the complexity of transcriptional programs coded by different cell types has been one of the central goals of cell biology. Using genome-wide location analysis, we examined how two different cell types generate different responses to the NF-kappaB signaling pathway. We showed that, after ...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-26868 | biostudies-arrayexpress
TranscriptomicsMonocyte vs Macrophage Study
Human intestinal macrophages contribute to tissue homeostasis in noninflamed mucosa through profound down-regulation of pro-inflammatory cytokine release. Here, we show that this down-regulation extends to Toll-like receptor (TLR)-induced cytokine release, as intestinal macrophages expressed TLR3-TL...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22373 | biostudies-arrayexpress
GenomicsHuman variation in PolII and NF-KappaB binding (ChIP-seq study with NF-KappaB)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19485 | biostudies-arrayexpress
TranscriptomicsTrap-80-dependence of TNF-alpha-induced genes
In fibroblasts, p65-dependent genes can be sub-divided, depending on whether they are Trap-80-dependent or -independent. To examine the generality of this grouping, we performed a microarray analysis of wild-type and Trap-80 knock-down fibroblasts, before and after stimulation of NF-kappaB activity...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-12697 | biostudies-arrayexpress
TranscriptomicsInterfering with Proximal TLR4 to NF-kappaB Signal Transduction in Human Monocytes
This study investigated the global effect of carbon monoxide (CO) gas (250 ppm) on LPS- induced gene expression in THP-1 cells. CO predominantly suppresses LPS-induced gene response. Of the CO-suppressed genes, 18% were transcription factors and most others were cytokines, chemokines and immune resp...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-16193 | biostudies-arrayexpress
TranscriptomicsSuppression of p53-mediated senescence by non-canonical NF-kappaB pathway mediated regulation of EZH2 expression
The NF-kappaB and p53 transcription factors control the expression of complex gene regulatory networks in response to many cell stresses and stimuli. This experiment describes gene expression profiling of cells depleted for EZH2, NF-kappaB2, RelB and p53. We find that EZH2 is the major effector of c...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-MTAB-1593 | biostudies-arrayexpress
GenomicsMouse livers lacking NF-kappaB RelA (p65) during bacteremia
Mouse livers lacking NF-kappaB RelA (p65) during bacteremia
PRJNA522786 | ENA
TranscriptomicsTNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
Classical Hodgkin lymphoma (cHL) is one of the most common malignant lymphomas. It is characterized by the presence of rare Hodgkin and Reed/Sternberg (HRS) cells embedded in an extensive inflammatory infiltrate. Constitutive activation of nuclear factor-kappaB (NF-kappaB) in HRS cells which transcr...
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15264 | biostudies-arrayexpress
TranscriptomicsEffect of heteronemin on gene expression profiles in chronic myelogenous K562 leukemia cells
Heteronemin is a sesterterpene first isolated from Hyrtios Erecta in 1976. In this study we decided to investigate the anti-cancer and anti-inflammatory potential of this marine natural compound at the transcriptomic level in chronic myelogenous K562 leukemia cells. Our results suggest that this se...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-16026 | biostudies-arrayexpress
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