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GenomicsThe NF-kB genomic landscape in lymphoblastoid B-cells
The nuclear factor kB (NF-kB) subunits RelA, RelB, c-Rel, p50 and p52 are each critical for B-cell development and function. To systematically characterize their responses to canonical and non-canonical NF-kB pathways activity, we performed ChIP-seq analysis in lymphoblastoid B-cells. We found a su...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-55105 | biostudies-arrayexpress
TranscriptomicsRole of NF-kB in aging
To address the role of NF-kB in aging in vivo, we utilized a well-characterized system that allows inducible and site-specific inhibition of NF-kB activity in murine skin. The hormone binding domain of the mutant estrogen receptor that is responsive to 4-hydroxytamoxifen (4-OHT) was fused to a mutan...
ORGANISM(S): Mus musculus 
2010-06-30 | E-GEOD-3845 | biostudies-arrayexpress
ModelsAhmedMobeen2021 - NF-kB Activation Model
NF-kappaB Activation Model includes the activation of both NFKB1:RELA and NFKB2:RELB for Canonical and Non-Canonical Pathway respectively. The model includes the pathway model integrated with post-translational modifications of NF-kB subunits that regulate the NFKB1:RELA and NFKB2:RELB activity. The...
2022-05-27 | MODEL2001290001 | BioModels
GenomicssiRNA knockdown screening of possible NF-kB p65 interactors influencing IL-1-NF-kB gene expression
siRNA knockdown screening of possible NF-kB p65 interactors influencing IL-1-NF-kB gene expression
PRJNA1023945 | ENA
TranscriptomicsCooperative Signaling Through the STAT3 and NF-kB Pathways in Subtypes of DLBCL
The activated B cell-like (ABC) subgroup of diffuse large B cell lymphoma (DLBCL) is characterized by constitutive activation of the NF-êB pathway. Here we show that the NF- êB pathway induces the expression of the cytokines IL-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of to...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-10009 | biostudies-arrayexpress
GenomicsRNA sequencing of NF-kB knockout (KO) U937 cells
RNA sequencing of NF-kB knockout (KO) U937 cells
PRJNA641643 | ENA
ProteomicsHAF prevents hepatocyte apoptosis and progression to MASH and hepatocellular carcinoma through transcriptional regulation of the NF-kB pathway
Background: HCC incidence is increasing worldwide due to the obesity epidemic, which drives metabolic dysfunction-associated steatohepatitis (MASH) that can lead to HCC. However, the molecular pathways driving MASH-HCC are poorly understood. We have previously reported that male mice with haploinsu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000095959 | MassIVE
TranscriptomicsIkB-like protein NFKBIZ regulates NF-kB signaling and is critical for survival of ABC DLBCL (NFKBIZ inhibition)
Constitutive activation of the nuclear factor-kappa B (NF-kB) pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent mutations of NF-kB regulators that cause constitutive activity of this oncogenic pathway have been identified. However, i...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46971 | biostudies-arrayexpress
TranscriptomicsIkB-like protein NFKBIZ regulates NF-kB signaling and is critical for survival of ABC DLBCL (MLN inhibition)
Constitutive activation of the nuclear factor-kappa B (NF-kB) pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent mutations of NF-kB regulators that cause constitutive activity of this oncogenic pathway have been identified. However, i...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46972 | biostudies-arrayexpress
GenomicsAMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-kB activation
AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-kB activation
PRJNA902278 | ENA
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