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TranscriptomicsComparison of class-B GATA overexpression transcriptomes
We have used Agilent whole genome arrays (v4) to compare the gene expression changes between 10-day-old Arabidopsis wild type seedlings and AtGNLox (AT4G26150), AtGNCox (AT5G56860), AtGATA17ox (AT3G16870), BdGATA6ox (BRADI3G08240) as well as the C-terminal mutation constructs AtGNL_LLM/AAAox and AtG...
ORGANISM(S): Arabidopsis thaliana 
2014-10-02 | E-GEOD-55442 | biostudies-arrayexpress
TranscriptomicsPhenocopy
Comprehensive in vitro expression profiling of small chemical compound inhibitors of TGFbR1 kinase activity. Additional file E-MTAB-265.additonal.1.zip contains excel file with Taqman data validating the array normalization method
ORGANISM(S): Homo sapiens 
2010-09-14 | E-MTAB-265 | biostudies-arrayexpress
TranscriptomicsRole and function of MYC in BCR-ABL1 driven pre-B cells
In order to investigate the function of MYC in ALL, we isolated bone marrow cells from conditional MYC knockout mice and transformed them with BCR-ABL1. In a second transduction the BCR-ABL1 driven pre-B cells were transformed either with CRE or empty vector control. Three days post transduction, to...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-30928 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptomes in class-B GATA mutants with cytokinin treatments
We have used Agilent whole genome arrays (v4) to compare the gene expression changes between 14 days-old Arabidopsis seedlings with or without cytokinin treatments in wild type as well as the following mutant genotypes: gnc gnl (AT5G56860, AT4G26150), gata16 gata17 gata17l (AT5G49300, AT3G16870, AT...
ORGANISM(S): Arabidopsis thaliana 
2016-03-10 | E-GEOD-71828 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
ProteomicsEngineered synthetic eukaryotic vesicles as anti-inflammatory drug delivery system to target Myd88
Mesenchymal stem cells (MSC) secrete naturally extracellular vesicles (EV) with a regenerative profile, and an increasing number of studies have focused on the employment of EV for therapeutic drug delivery. However, EV are usually produced by the cells at low quantities and packed with unnecessary ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033512 | Pride
Mesenchymal stem cells Extracellular vesicles Therapeutic drug delivery Quantitative proteomics Human 
TranscriptomicsPeriodic mRNA synthesis and degradation co-operate during cell cycle gene expression
Dynamic transcriptome profiling with metabolic labeling (4tU) (Sun et al. Genome Research 2012) was applied to synchronized S.cerevisiae cells to estimate labeled and total mRNA levels every 5 minutes for three complete cell cycles. The dataset comprises two time series from independent biological r...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-04 | E-MTAB-1908 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreatic islets from Hnf1a-deficient and wild type mice
Pancreatic islets were isolated from Hnf1a (Hepatocyte nuclear factor 1 alpha) knockout and wild-type mice and cultured ex vivo for two days in RPMI medium with 10% FBS before RNA extraction. The transcription profiles were obtained using Affymetrix GeneChip Mouse Genome 430A 2.0 arrays [Mouse430A_2...
ORGANISM(S): Mus musculus 
2009-03-21 | E-MEXP-1707 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreatic islets from heterozygous Hnf1a-mutant and wild type mice
Pancreatic islets were isolated from Hnf1a+/- (Hepatocyte nuclear factor 1 alpha) and wild-type mice and cultured ex vivo for two days in RPMI medium with 10% FBS before RNA extraction. The transcription profiles were obtained using Affymetrix GeneChip Mouse Genome 430 2.0 arrays [Mouse430_2].
ORGANISM(S): Mus musculus 
2009-03-21 | E-MEXP-1979 | biostudies-arrayexpress
TranscriptomicsRNA-seq of murine mesenchymal stem cells during differentiation to osteoblasts, treated with tofacitinib or baricitinib against vehicle control
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by synovial hyperplasia and progressive joint destruction. For treating inflammatory diseases, such as RA, the Janus kinase (JAK)-mediated signaling pathway has emerged as a therapeutic target. Therefore, JAK inhib...
ORGANISM(S): Mus musculus 
2020-02-12 | E-MTAB-8536 | biostudies-arrayexpress
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