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GenomicsExtensive changes in DNA methylation are associated with expression of mutant huntingtin [ChIP-seq]
The earliest stages of HuntingtonM-bM-^@M-^Ys disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin protein (HTT). To explore the hypothesis DNA methylation may be altered in cells expressing mutate...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-43429 | biostudies-arrayexpress
GenomicsExtensive changes in DNA methylation are associated with expression of mutant huntingtin [RRBS]
The earliest stages of Huntington’s disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin protein (HTT). To explore the hypothesis DNA methylation may be altered in cells expressing mutated HTT, we ...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-43432 | biostudies-arrayexpress
GenomicsExtensive changes in DNA methylation are associated with expression of mutant huntingtin [MeDIP-seq]
The earliest stages of Huntington’s disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin protein (HTT). To explore the hypothesis DNA methylation may be altered in cells expressing mutated HTT, we ...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-43430 | biostudies-arrayexpress
TranscriptomicsExtensive changes in DNA methylation are associated with expression of mutant huntingtin [mRNA-seq]
The earliest stages of Huntington’s disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin protein (HTT). To explore the hypothesis DNA methylation may be altered in cells expressing mutated HTT, we ...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-43431 | biostudies-arrayexpress
TranscriptomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (RNA-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48962 | biostudies-arrayexpress
GenomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing reveals key genes and immune homeostatic pathways activated in myeloid dendritic cells by Porphyromonas gingivalis 381 and its fimbrial mutants
Periodontitis affects 47.1% of adult population in the U.S. Porphyromonas gingivalis is an opportunistic oral pathogen that colonizes the oral mucosa, invades myeloid dendritic cells and accesses the bloodstream, brain, placenta and other organs in human with periodontitis. Periodontitis also sustai...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-67141 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
UnknownLopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.
Not available
S-EPMC8274471 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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