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TranscriptomicsTranscriptome conservation of the D. discoideum and D. purpureum developmental programs revealed through RNA-sequencing
Cross species comparison of genomes and transcriptomes is a powerful tool for understanding underlying biological processes, accurate functional classification of genes, and discovery of novel elements. The shift to next-generation sequencing platforms has tremendously accelerated the analysis of ge...
ORGANISM(S): Dictyostelium purpureum 
2010-03-12 | E-GEOD-17637 | biostudies-arrayexpress
UnknownToxicity and pharmacokinetics of actinomycin-D and vincristine in children and adolescents: Children's Oncology Group Study ADVL06B1.
Not available
S-EPMC8653953 | biostudies-literature
TranscriptomicsSelective inhibition of Homo sapiens M1 macrophages where SP140 mRNA is inhibited using siRNA
As part of our study in understanding the role of SP140 in inflammatory pathways in macrophages, we inhibited SP140 mRNA using siRNA. Peripheral blood mononuclear cells (PBMCs) were obtained from whole blood of healthy donors (from Sanquin Institute Amsterdam or from GSK Stevenage Blood Donation U...
ORGANISM(S): Homo sapiens 
2022-07-22 | E-MTAB-12011 | biostudies-arrayexpress
UnknownInvestigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification.
Not available
S-EPMC8466300 | biostudies-literature
GenomicsGenome-wide maps of histone modifications in Arabidopsis thaliana
Histone acetylation and methylation regulate gene expression in eukaryotes, but their effects on the transcriptome of a multicellular organism and on the transcriptomic divergence between species are still poorly understood. Here we present the first genome-wide 1-bp resolution maps of histone acety...
ORGANISM(S): Arabidopsis thaliana 
2011-02-02 | E-GEOD-22276 | biostudies-arrayexpress
UnknownCNS penetration of the CDK4/6 inhibitor ribociclib in non-tumor bearing mice and mice bearing pediatric brain tumors.
Not available
S-EPMC7029794 | biostudies-literature
TranscriptomicsCis- and trans- regulatory divergence between progenitor species determines gene-expression novelty in Arabidopsis allopolyploids
Gene-expression divergence between species shapes morphological evolution, but the molecular basis is largely unknown. Here we show cis- and trans-regulatory elements and chromatin modifications on gene-expression diversity in genetically tractable Arabidopsis allotetraploids. In Arabidopsis thalian...
ORGANISM(S): Arabidopsis arenosa x Arabidopsis thaliana 
2012-05-31 | E-GEOD-29687 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome
By using a novel high-throughput method, named chemical inference of RNA structures (CIRS-seq), that uses dimethyl sulfate (DMS), and N-cyclohexyl-N'-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMCT) to modify RNA residues in single-stranded conformation within native RNA secondary str...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-54106 | biostudies-arrayexpress
TranscriptomicsExpression data from rat INS-1E cells
Cytokine-induced beta-cell apoptosis is a key event for the death of pancreatic beta cells in the development of type-1 diabetes. We identified BRD0476 as a novel suppressor of cytokine-induced beta-cell apoptosis. We used microarrays to look for gene set(s) that are regulated by BRD0476. Rat INS-1E...
ORGANISM(S): Rattus norvegicus 
2012-12-14 | E-GEOD-42897 | biostudies-arrayexpress
UnknownOutcomes of children with well-differentiated fetal hepatoblastoma treated with surgery only: Report from Children's Oncology Group Trial, AHEP0731.
Not available
S-EPMC9474653 | biostudies-literature
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