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TranscriptomicsMicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer
Despite surgical treatment of stage I non-small cell lung cancer (NSCLC), one third of patients will eventually have a recurrence. Robust prognostic markers are required to better manage therapy options. MicroRNAs play important roles in human cancers. The purpose of this study is to identify miRNA ...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-29135 | biostudies-arrayexpress
MetabolomicsFate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics.
The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and metabolomics. Both cell culture media and cellular lysates were analyzed in dose-response and kinetic experiments on the HepaRG cell line. Re...
2024-02-07 | MTBLS4063 | MetaboLights
GenomicsDNase I hypersensitivity and algorithmic prediction of TF binding in early pancreatic mES directed differentiation
This dataset uses DNase-seq to profile the genome-wide DNase I hypersensitivity of mES and mES-derived cells along an early pancreatic lineage and provides the locations of putative Transcription Factor (TF) binding sites using the PIQ algorithm. DNase-seq takes advantage of the preferential cutting...
ORGANISM(S): Mus musculus 
2014-01-19 | E-GEOD-53776 | biostudies-arrayexpress
TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
GenomicsIKK-epsilon regulates the balance between the type I and type II interferon responses
Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, S...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33913 | biostudies-arrayexpress
TranscriptomicsInterleukin-27 is a potent inhibitor of cis HIV-1 replication in Monocyte-derived Dendritic Cells via a Type I Interferon-independent pathway
IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-44732 | biostudies-arrayexpress
TranscriptomicsType I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression
In acute HIV infection immune activation may provide target cells and drive virus replication, which innate immunity may limit. Thus, the net effects of inflammatory mediators, including type I interferon (IFN-I), are unclear. Here, we block IFN-I signaling during pathogenic acute SIV infection wit...
ORGANISM(S): Macaca mulatta 
2014-07-23 | E-GEOD-53690 | biostudies-arrayexpress
TranscriptomicsMF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I independent mechanism of action
Analysis of whole mouse muscle and inguinal lymph node gene expression signature induced after 6h by in-vivo intramuscularly administration of MF59, alum, CpG, resiquimod (R848), Pam3CSK4 and DMSO and PBS controls. Analysis of splenocyte gene expression signature induced by the same treatments after...
ORGANISM(S): Mus musculus 
2012-02-22 | E-MTAB-942 | biostudies-arrayexpress
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
TranscriptomicsYeast D10 Small ~ WT San I
Transcriptional profiling of parental S. cerevisiae San I cells in comparison with its translocant derivative D10 Small strain. The latter strain was obtained using Bridge Induced translocation technique between DUR3 gene (Chromosome VIII) and ADH1 gene (Chromosome XV), and exhibited an abnormal phe...
ORGANISM(S): Saccharomyces cerevisiae 
2010-09-03 | E-GEOD-23966 | biostudies-arrayexpress
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