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TranscriptomicsSox7 and Sox17
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-43234 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of V5 tagged Sox17 expressing ES cells
Analysis of the expression of KH2 embryonic stem cells inducibly expressing V5 tagged Sox17 protein. Results provide information on the endodermal gene expression program activated after Sox17 expression in ES cells. Total RNA extracted from 48 hours doxycycline induced compaired to non-induced Sox1...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-43233 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of F9 cells double knock-down for Sox7 and Sox17
Analysis of the expression of F9 cells after knockdown of Sox7 and Sox17 during their primitive endoderm differnetiation induction with retinoic acid. Results provide information on the endodermal gene expression program regulated by Sox7 and Sox17. Sox7 Sox17 double KD vs. control in F9 cells
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-43232 | biostudies-arrayexpress
GenomicsGenome-wide maps of Sox/Oct partnerships pluripotent and lineage-committed cells
We show here by using genome-wide ChIP-sequencing that lineage segregation involves multiple Sox/Oct partnership. In undifferentiated ES cells Oct4 interacts with Sox2 and both TFs bind on the 'canonical' motif, whereas in cells commited to PrE lineage Oct4 switches from Sox2 to Sox17 interaction an...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-43275 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in Cystic Fibrosis Airway Epithelium
Cystic fibrosis (CF) is one of the commonest lethal genetic diseases in which the role of microRNAs (miRNAs) has yet to be explored. We hypothesized that unique miRNA expression profiles exist in CF versus non-CF bronchial epithelial cells so the our aim was to investigate whether unique miRNA expre...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19431 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Klf4 and Klf5 in pluripotent mouse embryonic stem cells (ESCs)
We identified the binding profile of Klf4 and Klf5, which are both transcription facyors involved in the maintenance of pluripotency of ESCs by inhibiting their differentiation either into endoderm or mesoderm respectively. Undifferentiated mouse ESCs were used to identify Klf4 and Klf5 bidning site...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-49848 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing technology identifies specific genes expressed in the ICM of mouse embryos
RNA-seq data from whole mouse embryos at E3.75 (stage where the three cell types: TE, PrE and EPI are well resolved) and from dissected ICMs in order to identify genes expressed specifically in the ICM We used E3.75 whole mouse embryos at the blastocyst stage and immunosurgically dissected ICMs for ...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-44553 | biostudies-arrayexpress
TranscriptomicsFunGenES: INS-3-1: Expression profiling of CGR8 cells after downregulation of Klf4 or Klf5.
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at Inserm U846, Bron, France. Aim: Kru_ppel-like factors (Klf) 4 and 5...
ORGANISM(S): Mus musculus 
2014-04-28 | E-MTAB-1838 | biostudies-arrayexpress
TranscriptomicsFunGenES: INS-4-1: Expression profiling of CGR8 cells after upregulation of Klf4 or Klf5 expression.
This experiment is a follow-up experiment of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at Inserm U846, Bron, France. Aim: Kru_ppel-like fac...
ORGANISM(S): Mus musculus 
2014-04-28 | E-MTAB-1839 | biostudies-arrayexpress
TranscriptomicsExogenous Sulfide Reverses the Alteration of Transcriptional Profiling of the des1-1 Mutant (Arabidopsis thaliana)
Arabidopsis thaliana cells contain different O-acetylserine(thiol)lyase (OASTL) enzymes that catalyze the biosynthesis of cysteine. Recently, we have deeply investigated about one of the minor OASTL-like protein located in the cytosol, named DES1, highlighting some important clues about its metaboli...
ORGANISM(S): Arabidopsis thaliana 
2013-04-25 | E-GEOD-32566 | biostudies-arrayexpress
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