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TranscriptomicsTranscription profiling of murine macrophage-like RAW 264.7 cells treated with EdTx, protective antigen, or LPS for different length of time to examine the effect of EdTx on global transcriptional profiles.
Edema toxin (EdTx), which is a combination of edema factor and a binding moiety (protective antigen), is produced by Bacillus anthracis, the etiological agent of anthrax. EdTx is an adenylyl cyclase enzyme that converts adenosine triphosphate to adenosine-3',5'-monophosphate, resulting in interstiti...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4712 | biostudies-arrayexpress
TranscriptomicsHost gene expression profiling on children with any cause critical illness at retrieval or admission to paediatric critical care
We analysed data collected as part of the Biomarkers of Acute Serious Illness in Children (BASIC) study. BASIC was a prospective cohort study that enrolled critically ill children admitted to four PICUs in London and Eastern England, UK, during emergency transport by the Children’s Acute Transport S...
ORGANISM(S): Homo sapiens 
2025-09-30 | E-MTAB-15164 | biostudies-arrayexpress
TranscriptomicsStaging of biliary atresia at diagnosis by molecular profiling of the liver
BACKGROUND: Young age at portoenterostomy has been linked to improved outcome in biliary atresia, but pre-existing biological factors may influence the rate of disease progression. In this study, we aimed to determine whether molecular profiling of the liver identifies stages of disease at diagnosis...
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-15235 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of CD57+ and CD57- effector memory CD8 T cells in patients with type 1 diabetes
Type 1 diabetes is an autoimmune disease in which insulin-secreting β cells of the pancreatic islets are selectively destroyed. CD8 T cells are regarded as critical players in mediating β cell destruction and as a result, considerable effort has been expended to define CD8 T cell behaviour in this d...
ORGANISM(S): Homo sapiens 
2018-08-03 | E-MTAB-6727 | biostudies-arrayexpress
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
TranscriptomicsIntra-macrophage transcriptome of Salmonella enterica serovar Typhimurium 4/74 using strand-specific RNA-seq
Bacterial transcription is controlled by many transcription factors and promoters. Currently many promoters are mapped only in in vitro conditions. We use an intra-macrophage model to map the promoters and their expression in vivo. Transcriptome analysis of S.Typhimurium 4/74 within macrophages usin...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2015-07-30 | E-GEOD-59945 | biostudies-arrayexpress
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