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MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
TranscriptomicsSynergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A
Analysis of bone marrow derived macrophages (BMDM) incubated with dexamethasone&IL4 (Dexa+IL4), B16F1 tumor conditioned medium (cmB16), and B16F1 tumor conditioned medium supplemented with dexamethasone&IL4 (cmB16+dexa+IL4). Results allow detection of genes that require synergistic stimulation of tu...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-25707 | biostudies-arrayexpress
ProteomicsIdentification of p85beta protein interaction partners in ovarian cancer cells
p85beta is one of the regulatory subunits of the PI3K. Apart from its canonical role in binding to and regulating the p110 catalytic subunit, the protein may bind to other interacting proteins to perform other biological functions. In this study, the protein binding partners of p85beta were determin...
ORGANISM(S): Homo sapiens (Human) 
2024-12-23 | PXD052205 | Pride
Ip-ms Pi3k P85beta Immunoprecipitation-mass spectrometry 
TranscriptomicsHigh fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects
Early perturbations in vascular health can be detected by imposing subjects to a high fat (HF) challenge and measure response capacity. Subtle responses can be determined by assessment of whole-genome transcriptional changes. We aimed to magnify differences in health by comparing gene-expression cha...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-53232 | biostudies-arrayexpress
TranscriptomicsIntegrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
The saprophytic mold Aspergillus fumigatus produces small (2-3 µm) airborne spores (conidia) that can reach the lung alveoli upon inhalation. There, they encounter the surfactant-rich environment of the alveolar epithelium and initiate swelling and germination. Primary alveolar macrophages are essen...
ORGANISM(S): Homo sapiens 
2026-10-02 | E-MTAB-17130 | biostudies-arrayexpress
TranscriptomicsEffects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
Polyphenolic compounds, such as resveratrol, have recently received widespread interest due to their ability to mimic effects of calorie restriction. The objective of the present study was to gain more insight into the effects of 30 days resveratrol supplementation on adipose tissue morphology and u...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-42432 | biostudies-arrayexpress
TranscriptomicsMicroarray mRNA data of RPTEC/TERT1 cells exposed to nephrotoxic chemicals ochratoxin A and potassium bromate
Human renal proximal tubule cells (RPTEC/TERT1) were exposed to one of two nephrotoxic chemicals, ochratoxin A (OA) or potassium bromate (KB), or a vehicle control (CT). The exposure regime was a repeated dosing every 24h for 5 days followed by chemical washout and 3 days of recovery with medium ren...
ORGANISM(S): Homo sapiens 
2018-09-16 | E-MTAB-7048 | biostudies-arrayexpress
TranscriptomicsIGR_BREAST_EXON_AGILENT_STUDY_FA
We profiled breast cancer samples with exon arrays (244K Agilent Human exon) in order to identify exons associated with higher risk of relapse. This set contain 178 single dual color of samples (biopsies) versus normal breast reference (Normal breast Clontech) , 5 dye-swap (10 hybridizations) and...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-MTAB-1389 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of diverse human, mouse and pig cell-types infected with various Salmonella strains
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): mixed sample: human cell line AGS and Salmonella Typhimurium SL1344 
2015-12-11 | E-GEOD-60144 | biostudies-arrayexpress
UnknownPredicting food allergy: The value of patient history reinforced.
Not available
S-EPMC8246712 | biostudies-literature
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