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TranscriptomicsTranscription profiling of human cell lines MCF7, COLO-205 and SK-MEL-5 following treatment with PEP008
We previously identified the induction of growth arrest with phenotypic characteristics of senescence in melanoma cell lines sensitive to diterpene esters, indicating a therapeutic potential. Here we compared the cytostatic effects of two diterpene esters namely TPA (12-O-tetradecanoylphorbol-13-ac...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8742 | biostudies-arrayexpress
TranscriptomicsmRNA expression profiles of SK-N-AS neuroblastoma cells with induced ALK-wt, ALK-F1174L or ALK-R1275Q
Establishment of inducible SK-N-AS ALKwt, ALKF1174L and ALKR1275Q cell lines Human neuroblastoma SK-N-AS cells were electroporated with pcDNA6/TR (Invitrogen) using the NeonM-eM-( Transfection System (Life Techologies). Single cell clones were generated using blasticidin (7.5M-eM-5g/ml) and limited ...
ORGANISM(S): homo sapiens 
2015-05-04 | E-MTAB-3207 | biostudies-arrayexpress
ProteomicsMudPIT analyses of whole cell extracts from Y1 murine adrenocortical carcinoma cell line stimulated with serum or FGF2
Fibroblast growth factor 2 (FGF2) is well known as a promoter of cell proliferation, however, in some cellular contexts, it can induce cell cycle arrest or cell death. In Y1 murine adrenocortical carcinoma cell line, FGF2 induces G0/G1 transition but delays S-phase progression and permanently block ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-10-23 | MSV000081638 | MassIVE
TranscriptomicsRNA profiling by array of human skin melanoma Bro and SK-MEL-2
One of the components of the tumor progression of melanoma of the skin is the formation of drug resistance. Chemotherapeutic agents can affect the cell cycle, DNA repair. By influencing melanoma cells of the BRO and SK-MEL-2 lines, the effect of a cytostatic drug on the genomic profile was determine...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11399 | biostudies-arrayexpress
TranscriptomicsSynergistic effects of TRAIL and taurolidine on soft tissue sarcoma cell lines
Microarray analysis revealed differential gene expression patterns of rhabdomyosarcoma (A-204), leiomyosarcoma (SK-LMS-1) and epithelioid cell sarcoma (VA-ES-BJ) cells treated with TRAIL and/or taurolidine. To explore new therapeutic options in the treatment of sarcomas, we tested the antibiotic tau...
ORGANISM(S): Homo sapiens 
2013-03-17 | E-GEOD-36572 | biostudies-arrayexpress
ProteomicsGlobal analysis of cancer cell responses to USP9X inhibition
K-GG ubiquitin profiling of SK-MEL-2 and UO-31 cells treated with the selective USP9X inhibitor WEHI-092 at 10 µM for 30 min, 6 h, and 24 h (and DMSO-treated control). This dataset is the matched global quantitative proteomics data.Sample IDs:#1-5 Control 30 min UO-31#6-10 WEHI-092 30 min UO-31#11-1...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD073798 | Pride
TranscriptomicsFOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma
Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic ...
ORGANISM(S): Homo sapiens 
2014-10-17 | E-GEOD-62419 | biostudies-arrayexpress
TranscriptomicsHox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma [cell line_genex_44k]
Single-color gene expression profiles from 2 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon HOXC9 re-expression, we analyzed gene expression profiles of IMR-32 and SK-N-AS cells after Hox-C9 induction using ...
ORGANISM(S): Homo sapiens 
2013-03-28 | E-GEOD-45545 | biostudies-arrayexpress
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
TranscriptomicsPermissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68
Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. This therapy relies on efficient replication of virus in tumor cells in vivo with minimal or no replication in normal tissues. We recently described GLV-1h68 as a modified Vaccinia Virus (VACV) constr...
ORGANISM(S): Homo sapiens 
2012-03-24 | E-GEOD-28472 | biostudies-arrayexpress
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