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MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
TranscriptomicsIdentification of ETO2-GLIS2 transcriptional targets
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-05 | E-MTAB-4332 | biostudies-arrayexpress
UnknownEvaluation of Mineralocorticoid Receptor Antagonism on Changes in NT-proBNP Among Persons With HIV.
Not available
S-EPMC8664688 | biostudies-literature
TranscriptomicsTranslation State Array Analysis of Thrombin Stimulated Human Endothelial Cells
Confluent human umbilical vein endothelial cells (HUVECs) were exposed to Thrombin (2 U/mL) for 2 hours. Ribosomal profiling via gradient centrifugation and fractionation was used to separate monosome, or under-translated, and polysome, or actively translated, mRNA species that were then used to pr...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4919 | biostudies-arrayexpress
TranscriptomicsLsd1 coordinates trophoblast development by retaining stem cells in their niche and directing cell fate
Stem cells reside in specific niches providing stemness-maintaining environments. Thus, the regulated migration from these niches is associated with differentiation onset. However, mechanisms retaining stem cells in their niche remain poorly understood. Here, we show that the epigenetic regulator ly...
ORGANISM(S): Mus musculus 
2014-01-17 | E-GEOD-38277 | biostudies-arrayexpress
UnknownAcute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients.
Not available
S-EPMC7833668 | biostudies-literature
TranscriptomicsPromiscuous RNA binding by PRC2
Polycomb repressive complex-2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. Long non-coding RNAs (lncRNAs) recruit PRC2 to chromatin, but the general role of RNA in maintaining repressed chromatin is unknown. ChIP-seq, combined with RNA-seq, i...
ORGANISM(S): Homo sapiens 
2013-09-28 | E-GEOD-50177 | biostudies-arrayexpress
TranscriptomicsIdentification of polyA sites in Drosophila melanogaster
The 3' ends of most Drosophila melanogaster genes are poorly annotated or are determined by only a single EST or cDNA clone. To enhance the annotation of poly(A) site use in Drosophila, we performed deep sequencing on RNA isolated from 29 dissected tissues using an approach designed to enrich for p...
ORGANISM(S): Drosophila melanogaster 
2011-11-23 | E-GEOD-33905 | biostudies-arrayexpress
TranscriptomicsImprinting RNAseq
Long-term hematopoietic stem cells (HSCs), short-term HSCs and multipotent progenitor cells (MPPs) were isolated from bone marrow of four mouse strains (WT, H19-deletion, Igf1r-deletion, and double-deletion) and expression profiled with RNAseq. The behavior of the transcriptomes, and in particular...
ORGANISM(S): Mus musculus 
2013-08-12 | E-MTAB-1628 | biostudies-arrayexpress
GenomicsIdentification of ETO2-GLIS2 targets by ChIP-sequencing
Acute megakaryoblastic leukemia (AMKL) is a subtype of leukemia primarily diagnosed in childhood and generally associated with poor prognosis. Genetic alterations found in de novo childhood AMKL include the OTT-MAL fusion, MLL and NUP98 fusions and the recently identified ETO2-GLIS2 fusion that invo...
ORGANISM(S): Homo sapiens 
2017-05-22 | E-MTAB-4367 | biostudies-arrayexpress
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