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TranscriptomicsGene expression profiling reveals mast cell-dependent inflammation in the meninges in early EAE.
The meninges are generally considered relatively inert tissues that house the CSF and provide protection for the brain and spinal cord. However, our previous studies using Kit mutant (Kit W/Wv) mast cell-deficient mice demonstrated that mast cells residing in the dura mater and pia mater exacerbate ...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-37191 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownEfficacy and safety of adjunctive lacosamide in the treatment of primary generalised tonic-clonic seizures: a double-blind, randomised, placebo-controlled trial.
Not available
S-EPMC7509528 | biostudies-literature
UnknownThirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Not available
S-EPMC3140055 | biostudies-literature
UnknownOverlapping genetic architecture between Parkinson disease and melanoma.
Not available
S-EPMC7379325 | biostudies-literature
UnknownGlobal, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
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S-EPMC4165626 | biostudies-literature
UnknownGenome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.
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S-EPMC7255059 | biostudies-literature
UnknownCell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.
Not available
S-EPMC6211648 | biostudies-literature
UnknownGenome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
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S-EPMC3674797 | biostudies-literature
UnknownEnhancer AAV toolbox for accessing and perturbing striatal cell types and circuits.
Not available
S-EPMC11463465 | biostudies-literature
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