Sort   by:  
 Page size 
TranscriptomicsTranscription profiling by array of prostate cancer cell line PC-3 ectopically expressing miR-34c to identify genes regulated by this microRNA
In this study we set out to characterize the mechanisms by which miR-34c deregulation contribute to PCa progression. The genes regulated by miR-34c in the prostate cancer cell line PC3 were identified by microarray analyses, and the top biofunctional pathways enriched for identified genes were found...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-41322 | biostudies-arrayexpress
ProteomicsExtracellular vesicles from osteogenic differentiated human BMSCs
Pathological processes like osteoporosis or steroid-induced osteonecrosis of the hip are accompanied by increased bone marrow adipogenesis. Such disorder of adipogenic/osteogenic differentiation, which affects also bone marrow derived mesenchymal stem cells (BMSCs) contributes to bone loss during ag...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035845 | Pride
Ev Bmsc 
ProteomicsStructural and functional fine mapping of cysteines in mammalian glutaredoxin reveal a hierarchy of susceptibility to oxidative inactivation
Protein-S-glutathionylation (PSSG) is a post-translational modification involving the conjugation of glutathione to reactive protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases that regulate this process by performing the r...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD026486 | Pride
Molecular dynamics Glutathione Multiscale modeling Redox S-glutathionylation Quantum mechanics 
TranscriptomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (methylation data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56382 | biostudies-arrayexpress
ProteomicsHuman HDL 2D-LC-MS/MS
Besides modulation of reverse cholesterol transport, high density lipoprotein (HDL) is able to modulate vascular function by stimulating endothelial nitric oxide synthase. Recently, it could be documented that this function of HDL was significantly impaired in patients with chronic heart failure (CH...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080857 | MassIVE
TranscriptomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (gene expression data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56381 | biostudies-arrayexpress
TranscriptomicsProgrammed fluctuations in sense/anti-sense transcript ratios drive sexual differentiation in Schizosaccharomyces pombe
Strand specific RNA sequencing of S. pombe revealed a highly structured programme of ncRNA expression at over 600 loci. Waves of antisense transcription accompanied sexual differentiation. A substantial proportion of ncRNA arose from mechanisms previously considered to be largely artefactual, includ...
ORGANISM(S): Schizosaccharomyces pombe 
2011-12-20 | E-GEOD-28113 | biostudies-arrayexpress
GenomicsMediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA
CCCTC-binding factor (CTCF) is a DNA-binding protein that plays important roles in chromatin organization, though the mechanism by which CTCF carries out these functions is not fully understood. Recent studies show that CTCF recruits the cohesin complex to insulator sites and that cohesin is require...
ORGANISM(S): Homo sapiens 
2010-11-16 | E-GEOD-24126 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptional profiling of the purple sulfur bacterium Allochromatium vinosum DSM 180T during growth on different reduced sulfur compounds [Set1]
The purple sulfur bacterium Allochromatium vinosum DSM 180T is one of the best studied sulfur-oxidizing anoxygenic phototrophic bacteria and has been developed into a model organism for laboratory-based studies of oxidative sulfur metabolism. Here, we took advantage of the organismM-bM-^@M-^Ys high ...
ORGANISM(S): Allochromatium vinosum DSM 180 
2013-07-29 | E-GEOD-44040 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptional profiling of the purple sulfur bacterium Allochromatium vinosum DSM 180T during growth on different reduced sulfur compounds [Set2]
The purple sulfur bacterium Allochromatium vinosum DSM 180T is one of the best studied sulfur-oxidizing anoxygenic phototrophic bacteria and has been developed into a model organism for laboratory-based studies of oxidative sulfur metabolism. Here, we took advantage of the organismM-bM-^@M-^Ys high ...
ORGANISM(S): Allochromatium vinosum DSM 180 
2013-07-29 | E-GEOD-44041 | biostudies-arrayexpress
Sort   by:  
 Page size