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ProteomicsAging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis
Background and Aims Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire ‘gain-of-function’ isoDGR motifs that might play a role in ather...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD024380 | Pride
Vascular inflammation Atherosclerosis Isodgr motif Fibronectin Integrin Deamidation 
ProteomicsCysteine thiol trioxidation induce aging
LC-MS/MS proteomic method is used to coduct skin and lungs proteomics profiling. Many protein with cysteine thiol trioxidation were identified in tissues of old mice. the modified proteins are predicted to induce celllular aging.
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD037908 | Pride
Lc-ms/ms Lungs Skin 
ProteomicsVascular bed systematic profiling unravels endothelial and glycocalyx dysregulations in experimental high salt hypertension
Objective: Considerable evidence links dietary salt intake with the development of hypertension, left ventricular hypertrophy, and increased risk of stroke and coronary heart disease. Despite extensive epidemiological and basic science interrogation of the relationship between high salt (HS) intake ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD031228 | Pride
Cardiovascular disease  endothelial cell dysfunction  glycocalyx  high salt diet  hypertension  mass spectrometry  proteomics   
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