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TranscriptomicsNgn2 induces diverse neuronal lineages from human pluripotency
Human neurons engineered from induced pluripotent stem cells (iPSCs) through Neurogenin 2 (Ngn2) overexpression are widely used to study neuronal differentiation mechanisms and to model neurological diseases. However, the differentiation paths and heterogeneity of emerged neurons have not been fully...
ORGANISM(S): Homo sapiens 
2021-08-05 | E-MTAB-10632 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of Ngn2-induced neurons from the pluripotent stem cells of great apes
We generated induced excitatory sensory neurons (iNeurons, iNs) from pluripotent stem cells of great apes (Human, Chimpanzee and Bonobo) by expressing the transcription factor neurogenin 2 (Ngn2). Single cell-RNA sequencing was performed to identify gene expressions differing in dendrite and synapse...
ORGANISM(S): Pan paniscus 
2020-12-15 | E-MTAB-9233 | biostudies-arrayexpress
GenomicsNgn2 induces diverse neuronal lineages from human pluripotency
Ngn2 induces diverse neuronal lineages from human pluripotency
PRJEB46177 | ENA
TranscriptomicsGenome-wide expression analysis of human fibroblasts and converted neurons
Human fibroblasts can be directly converted into cholinergic neurons by Neurogenin 2 (Neurog2 or NGN2) under the treatments of small molecules. Genome-wide analysis of gene expression was performed to examine the similarity of converted neurons to samples from human brain or spinal cord. Total RNA o...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-45954 | biostudies-arrayexpress
UnknownNGN2 induces diverse neuron types from human pluripotency.
Not available
S-EPMC8452516 | biostudies-literature
GenomicsTesting effects of cell density on NGN2 iN transcriptom
Testing effects of cell density on NGN2 iN transcriptom
PRJNA1142395 | ENA
UnknownEarly Reprogramming Intermediates Enable Direct Neuronal Conversion Via NGN2.
Not available
S-EPMC12868028 | biostudies-literature
ProteomicsExtended NGN2 Expression in iPSCs Dramatically Enhances Purity of Neuronal Cultures
iPSC-derived neuronal cultures can provide valuable insights into the pathogenesis of neurological disease. However, single cell iPSC clones with NGN2 and mCherry show spontaneous loss of mCherry fluorescence, leading to questions about the homogeneity of neurons derived from apparently heterogeneou...
ORGANISM(S): Ipscs Homo Sapiens (ncbitaxon:9606) 
2025-06-19 | MSV000098268 | MassIVE
UnknownWNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression.
Not available
S-EPMC7666497 | biostudies-literature
TranscriptomicsExpression data from chick embryos overexpressing NEUROG2 or NEUROG2AQ in the neural tube
The proneural NEUROG2 is essential for neuronal commitment, cell cycle exit and neuronal differentiation. Characterizing genes networks regulated downstream of NEUROG2 is therefore of prime importance. To identify NEUROG2 early response genes, we combined gain of function in the neural tube with a g...
ORGANISM(S): Gallus gallus 
2012-05-04 | E-GEOD-37782 | biostudies-arrayexpress
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