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UnknownRP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion.
Not available
S-EPMC3307985 | biostudies-literature
UnknownNgn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation.
Not available
S-EPMC12108711 | biostudies-literature
UnknownEffects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3.
Not available
S-EPMC6671084 | biostudies-literature
UnknownA mechanistic study of Toxoplasma gondii ROP18 inhibiting differentiation of C17.2 neural stem cells.
Not available
S-EPMC5701453 | biostudies-literature
TranscriptomicsEfficient generation of lower induced Motor Neurons by coupling Ngn2 expression with developmental cues
Human pluripotent stem cells (hPSCs) are a powerful tool for disease modelling of hard-to-access tissues (such as the brain). Current protocols either direct neuronal differentiation with small molecules or use transcription-factor-mediated programming. In this study, we couple overexpression of tra...
ORGANISM(S): Homo sapiens 
2022-12-05 | GSE219112 | GEO
UnknownEfficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.
Not available
S-EPMC10117176 | biostudies-literature
ProteomicsA functional and omics roadmap for human induced glutamatergic neuron: fine-tuning of culture conditions for pathophysiological studies
Induced glutamatergic neurons (iGluNeurons) generated via Neurogenin-2 overexpression in human pluripotent stem cells constitute a powerful model system for studying human neuronal maturation and function. Despite their growing use in disease modelling and drug screening, NGN2-based differentiation ...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-09-14 | PXD070249 | Pride
Human induced pluripotent stem cells Neuronal excitability Ngn2-mediated differentiation Proteomics. Human glutamatergic neurons 
UnknownPeripheral nerve injury induces adult brain neurogenesis and remodelling.
Not available
S-EPMC5264155 | biostudies-literature
UnknownDPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders.
Not available
S-EPMC11138811 | biostudies-literature
TranscriptomicsDPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders
The DPYSL2/CRMP2 gene encodes a microtubule-stabilizing protein crucial for neurogenesis and is associated with numerous psychiatric and neurodegenerative disorders including schizophrenia, bipolar disorder, and Alzheimer's disease. DPYSL2 generates multiple RNA and protein isoforms, but few studies...
ORGANISM(S): Homo sapiens 
2024-05-27 | GSE268103 | GEO
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