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Validation of lung metastasis signature (LMS) and its association with risk of developing lung metastasis and with primary tumor size. Experiment Overall Design: 58 tumor samples
ORGANISM(S): Homo sapiens 
Brain metastasis is one of the most feared complications of cancer and the most common intracranial malignancy in adults. Its underlying mechanisms remain unknown. From breast cancer patients with metastatic disease we isolated cell populations that aggressively colonize the brain. Transcriptomic an...
ORGANISM(S): Homo sapiens 
Immune checkpoint inhibitor and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential for cancers with high tumor mutation burden (TMB). Here, we employed mass spectrometry (MS)-based proteogenomic large-scale profiling to identify potential immunogenic human leukocyte ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD022949 | Pride
Immunotherapy has shown great therapeutic potential for cancers with high tumor mutational burden (TMB), but much less promise for cancers with low TMB. One primary approach for adoptive lymphocyte transfer-based immunotherapy is to target the somatic mutated peptide neoantigens and cancer testis (C...
ORGANISM(S): Homo sapiens (Human) 
2021-12-07 | PXD019774 | Pride
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