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TranscriptomicsGlobal methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders
Autism is currently considered a multigene disorder with epigenetic influences. To investigate the contribution of DNA methylation to autism spectrum disorders, we have recently completed large-scale methylation profiling by CpG island microarray analysis of lymphoblastoid cell lines (LCL) derived ...
ORGANISM(S): Homo sapiens 
2010-04-27 | E-GEOD-21395 | biostudies-arrayexpress
TranscriptomicsGene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by delayed/abnormal language development, deficits in social interaction, repetitive behaviors and restricted interests. The heterogeneity in clinical presentation of ASD, likely due to different etiologies, complicates ...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-15402 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of lymphoblastoid cell lines from autistic and nonaffected sib pairs
Despite the identification of numerous autism susceptibility genes, the pathobiology of autism remains unknown. The present “case-control” study takes a global approach to understanding the molecular basis of autism spectrum disorders based upon large-scale gene expression profiling. DNA micro...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-15451 | biostudies-arrayexpress
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