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ProteomicsTwo DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids
In higher eukaryotes, a single DOT1 histone H3 lysine 79 (H3K79) methyltransferase processively produces H3K79me2/me3 from me0 through histone H2B mono-ubiquitin interaction. The early-branched kinetoplastid Trypanosoma brucei harbors the essential H3K76 di-methyltransferase DOT1A and the non-essent...
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-09 | MSV000090680 | MassIVE
ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
TranscriptomicsRNA sequencing (RNA-SEQ) of Dnmt1 and Dnmt3a conditional knockout mice
Purpose: Epigenetic regulation contributes to pathogenesis of neurondegenerative disease. We found that dis-regulation of a 242-gene subnetwork related to DNA methylation regulated neuronal differentiation are common in AD and HD. There are two DNA methyltransferases, DNMT1 and DNMT3A, in the subn...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-58261 | biostudies-arrayexpress
TranscriptomicsDifference in gene expression between WT (Col-0) and atxrn4-3 mutant under non-stress and heat stress condition
Arabidopsis 5’-3’ exoribonuclease, AtXRN4, a homolog of yeast Xrn1p, functions in degradation of uncapped RNAs after de-capping step. While Xrn1p-dependent on plant XRN4’s targets for degradation is still limited. For understanding biological function of AtXRN4, we tested survivability of atxrn4 mut...
ORGANISM(S): Arabidopsis thaliana 
2015-07-14 | E-GEOD-66369 | biostudies-arrayexpress
Transcriptomicsp53- repressed miRNAs are involved with E2F in a feed forward loop promoting proliferation
There is a distinctive miRNA expression profile between early (young) and replicative senescence (old). We observed a cluster of miRNAs that were repressed upon senescence in both MRC-5 and WI-38 fibroblast cells. miRNAs profiling in young and senescence human emryonic fibroblasts (MRC-5 and WI-38)
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-12821 | biostudies-arrayexpress
TranscriptomicsSalivary gland during development and onset of xerostomia in murine model of SjM-CM-6gren's syndrome-like disease
Differential gene expression in the salivary gland during development and onset of xerostomia in SjM-CM-6grenM-bM-^@M-^Ys syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from t...
ORGANISM(S): Mus musculus 
2009-04-11 | E-GEOD-15640 | biostudies-arrayexpress
UnknownEffectiveness and implementation of lower-intensity weight management interventions delivered by the non-specialist workforce in postnatal women: a mixed-methods systematic review.
Not available
S-EPMC11008719 | biostudies-literature
TranscriptomicsTolerogenic dendritic cells protect against acute kidney injury
We use tolDCs from syngeneic (C57BL6) and allogeneic (BALB/c) mice to show potent renoprotective abilities in a ischemia reperfusion AKI model. Dendritic cells were derived from mice bone marrow and cultured for 7 days with GM-CSF and IL-4. Tolerogenic DCs were cultured in the same DC media but with...
ORGANISM(S): Mus musculus 
2024-11-25 | E-MTAB-14618 | biostudies-arrayexpress
UnknownCopy number variation in CEP57L1 predisposes to congenital absence of bilateral ACL and PCL ligaments.
Not available
S-EPMC4642759 | biostudies-literature
GenomicsGenome-wide profiling of trimethylated histone H3 lysine 27 (H3K27me3) in wide-type, brm, clf, and brm clf mutant seedlings
By using ChIP-seq, we found that loss of BRM activity in developing seedlings leads to ectopic and increased H3K27me3 deposition at several hundred genes, indicating the critical role of BRM in preventing the inappropriate deposition of this histone mark. Removal of CLF in brm mutant could partciall...
ORGANISM(S): Arabidopsis thaliana 
2015-03-09 | E-GEOD-53620 | biostudies-arrayexpress
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