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MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
TranscriptomicsRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
We assessed the roles of repopulating microglia in brain repair using mouse models. In this project, we show that removal of microglia from the mouse brain has little impact on the outcome of TBI but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a ...
ORGANISM(S): Mus musculus 
2020-02-15 | E-MTAB-8765 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profile of human induced pluripotent stem cells at single cell resolution.
We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlexTM and TeSRTM-E8TM media. Single-cell transcriptome sequencing was performed for 20,962 cells from two cell lines grown in the two media. Analysis of transcriptomic profile ...
ORGANISM(S): Homo sapiens 
2019-05-08 | E-MTAB-6524 | biostudies-arrayexpress
TranscriptomicsSpatially resolved transcriptomes of healthy mammalian kidneys illustrate the molecular complexity and interactions of functional nephron segments
We performed spatial transcriptomics sequencing (ST-seq) to resolve geographically defined transcriptome-wide gene expression within the tissue context of four human and six mouse kidneys. This application of ST-seq within healthy mammalian kidneys demonstrates the integration of transcriptional pro...
ORGANISM(S): Homo sapiens 
2022-06-16 | E-MTAB-11721 | biostudies-arrayexpress
TranscriptomicsCompetitive regulation of HOPX transcription governs cardiomyocyte maturation
This study establishes the homeodomain only protein, HOPX, as a determinant controlling the molecular switch between cardiomyocyte progenitor and maturation gene programs. This dataset is about time-course CAGE (capped analysis of gene expression) data with genome-wide active transcription footprint...
ORGANISM(S): Homo sapiens 
2022-05-21 | E-MTAB-11719 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identified that loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition
We used spatially resolved transcriptomics to define the cellular diversity within a sonic hedgehog (SHH) patient-derived model of Medulloblastoma (MB) and identify how cells specific to a transcriptional state or spatial location are pivotal in responses to treatment with the CDK4/6 inhibitor, Palb...
ORGANISM(S): Homo sapiens 
2022-06-16 | E-MTAB-11720 | biostudies-arrayexpress
TranscriptomicsscRNA-seq in 79 fibroblast cell lines and 31 reprogrammed induced pluripotent stem cell lines for sceQTL analysis
Here, we performed scRNA-seq on 64,018 fibroblasts from 79 donors and mapped expression quantitative trait loci (eQTLs) at the level of individual cell types. We demonstrate that the majority of eQTLs detected in fibroblasts are specific to an individual cell subtype. To address if the allelic effec...
ORGANISM(S): Homo sapiens 
2021-02-22 | E-MTAB-10060 | biostudies-arrayexpress
UnknownUV-blocking and mechanically reinforced starch films incorporating Ce-UiO-66 nanoparticles for food packaging applications
Not available
S-EPMC12380046 | biostudies-literature
UnknownZIKV Inhibitors Based on Pyrazolo[3,4-d]pyridazine-7-one Core: Rational Design, In Vitro Evaluation, and Theoretical Studies.
Not available
S-EPMC10753549 | biostudies-literature
ProteomicsLF2 phosphorylation of the CDKL5 activation loop controls CDKL5’s activity
Cdkl5 Deficiency Disorder (CDD) is caused by variants in the protein kinase CDKL5, leading to symptoms such as seizures, developmental delay, and severe intellectual disability. The Chlamydomonas homologue of human CDKL5 is the flagellar protein LF5, whose absence results in a long flagella phenotyp...
ORGANISM(S): Chlamydomonas reinhardtii 
2025-11-18 | PXD066877 | Pride
Chlamydomonas Cilia Cdkl5 deficiency disorder Ciliopathy Intraflagellar transport Kinase Flagella 
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