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TranscriptomicsSmoking is Associated with Shortened Airway Cilia
Background: Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length. Based on models of mucociliary clearance predicting cilia length must exceed th...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-16696 | biostudies-arrayexpress
MetabolomicsMetabolomics of cilia and modulation of renal microcirculation
Not available
ORGANISM(S): Rattus norvegicus 
ST000756 | MetabolomicsWorkbench
TranscriptomicsAltered Expression of Intraflagellar Transport Genes is Associated with Short Cilia in Smoking and COPD
Study Smoking and COPD are associated with decreased mucociliary clearance and healthy smokers have shorter cilia in the large airway than nonsmokers. Intraflagellar transport (IFT) is the process by which cilia are produced and maintained. We assessed expression of IFT-related genes in smokers and ...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-43939 | biostudies-arrayexpress
TranscriptomicsGene expression in control and cilia deleted growth plate chondrocytes
Proliferative zone chondrocytes were microdissected from control and Ift88-deleted growth plates to determine gene expression profiles regulated by primary cilia. Four total samples were analyzed. Two biological replicates of proliferative zone chondrocytes microdissected from control mice and two b...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-35003 | biostudies-arrayexpress
ProteomicsDSSO Crosslinking of Intact Tetrahymena Thermophila Cilia
The MS-cleavable crosslinker, DSSO, was added to cilia isolated from Tetrahymena thermophila. After digestion crosslinked peptides were enriched by size exclusion chromatography. Data were collected using an MS2/MS3 method. Analysis was done using the XlinkX node of PD2.3 and a fasta file generat...
ORGANISM(S): Tetrahymena Thermophila (ncbitaxon:5911) 
2022-07-19 | MSV000089917 | MassIVE
ProteomicsA conserved mechanism for the retrieval of polyubiquitinated proteins from cilia
The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways and cause ciliopathies. Although K63-linked ubiquitination a...
ORGANISM(S): Chlamydomonas reinhardtii Leishmania tarentolae Sus scrofa domesticus (domestic pig) 
2026-06-29 | PXD062789 | Pride
Intraflagellar transport Flagella Hedgehog signaling Ubiquitin Cilia 
ProteomicsProteome expression profile of primary cilia deficient mIMCD3 cells
We characterized the protein expression profiles in ciliated kidney tubular epithelial cells and studied the changes upon loss of primary cilia.
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD035290 | Pride
Cilia Autophagy Ripk3 Ciliopathies Nphp Kidney Necroptosis 
ProteomicsProteomics of mouse ependymal cilia
Two 75-cm2 flasks of ependymal cells derived from ten E18.5 C57BL/6J mouse embryos at the day 10 post serum starvation were harvested and motile cilia were collected for mass spectrometry analysis.
ORGANISM(S): Mus Musculus 
PXD029174 |
TranscriptomicsGenome-wide gene expression analysis in primary ciliary dyskinesia patients
We performed whole genome gene expression profiling in bronchial biopsies from PCD patients. We used the Quality Threshold clustering algorithm to identify groups of genes that revealed highly correlated RNA expression patterns in the biopsies. The largest cluster contained 372 genes and was signifi...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-25186 | biostudies-arrayexpress
ProteomicsCilia proteome isolated from the multi-ciliated cells of Xenopus laevis embryo epidermis
We characterized the cilia proteome isolated from the multi-ciliated cells of Xenopus laevis embryo epidermis.
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-11-15 | PXD010722 | Pride
Multiciliated cells Xenopus laevis Cilia proteome 
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