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ProteomicsHuman RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3. To mediate necroptosis, RIPK3 must stably interact with, and phosphorylate the pseudokinase domain of MLKL. While ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-30 | PXD033488 | Pride
Tnf Programmed necrosis Pseudokinase Protein kinase Ripk1 
ProteomicsUbiquitylation of RIPK3 beyond-the-RHIM limits RIPK3 activity and cell death
Pathogen recognition receptors and TNF superfamily members engage Receptor Interacting Serine/threonine Kinase-3 (RIPK3) to activate programmed cell death, including MLKL-mediated necroptosis and caspase-8-dependent apoptosis. However, the post-translational control of RIPK3 signalling is not fully ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD026533 | Pride
Ripk3 Mlkl Apoptosis Caspase-8 Ubiquitin Cell death Necroptosis 
TranscriptomicsTranscriptional profiles of PA1 teratoma cells transfected by RIPK1, RIPK2, RIPK3, or RIPK4
RIPK4 but not the related kinases RIPK1, RIPK2, and RIPK3 caused similar transcriptional changes to Wnt3a. PA1 cells were transfected by 8ug RIPK1, RIPK2, RIPK3, or RIPK4 for 48h, RNA were extracted and sequenced.
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-43362 | biostudies-arrayexpress
ProteomicsProteomic analysis of TRAIL-induced endogenous RIPK3-dependent necrosome complex
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a well-known inducer of apoptosis via formation of the primary death-inducing signaling complex (TRAIL-DISC) at the level of membrane death receptors (DR4 and DR5) which recruit successively FADD and caspase-8. TRAIL can also induce ...
ORGANISM(S): Colon Homo sapiens (Human) 
2021-03-18 | PXD003383 | Pride
Ripk3-dependent necrosome  disc  mass spectrometry  trail  trim21 
GenomicsIdenitifying RIPK3 dependent genes in neurons expressing RIPK3-activatable system
Idenitifying RIPK3 dependent genes in neurons expressing RIPK3-activatable system
PRJNA1181549 | ENA
GenomicsAssessing RIPK3 dependent genes in death-resistant and death-susceptible MEFs encoding activatable RIPK3-system
Assessing RIPK3 dependent genes in death-resistant and death-susceptible MEFs encoding activatable RIPK3-system
PRJNA1181905 | ENA
GenomicsRIPK3 is a tumor suppressor in mesothelioma
RIPK3 is a tumor suppressor in mesothelioma
PRJNA666445 | ENA
GenomicsRNA-sequencing of control (CTL), MLKL -/- (MLKL) and RIPK3-/- (RIPK3) 3T3-L1 preadipocytes (J0) or differentiated (J7) cells.
RNA-sequencing of control (CTL), MLKL -/- (MLKL) and RIPK3-/- (RIPK3) 3T3-L1 preadipocytes (J0) or differentiated (J7) cells.
PRJNA831810 | ENA
GenomicsRIPK3-dependent transcriptional program in flavivirus-infected neurons
RIPK3-dependent transcriptional program in flavivirus-infected neurons
PRJNA503843 | ENA
ProteomicsRIPK3 is released into Extracellular Vesicles during Necroptosis through a Rab27 independent mechanism
Extracellular vesicles (EVs) are important mechanisms used by cells to release biomolecules. A common necroptosis effector— mixed lineage kinase like (MLKL)--- was recently found to participate in the biogenesis of small and large EVs independent of its function in necroptosis. The objective of the ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-14 | PXD031224 | Pride
Lysosomal exocytosis Ripk3 Sevs Mlkl Necroptosis Proteomics 
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