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ProteomicsAnalysis of RIPK1 phosphorylation in vitro
This study aims at determining which RIPK1 residues are phosphorylated.
ORGANISM(S): Homo sapiens (Human) 
2018-09-25 | PXD008518 | Pride
Ms Phosphorylation Ripk1 
ProteomicsO-GlcNAcylation of RIPK1 Rescues Red Blood Cells from Necroptosis
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O-GlcNAcylation contributes to the regulation of ne...
ORGANISM(S): Homo sapiens (Human) 
2023-06-06 | PXD042579 | Pride
Necroptosis O-glcnac Ripk1 
TranscriptomicsTNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP
The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or intestinal bowel disease (IBD). Interestingly, XLP-2 patients display high levels of IL-18 in the serum even while in stable ...
ORGANISM(S): Mus musculus 
2021-03-01 | E-MTAB-10103 | biostudies-arrayexpress
GenomicsRIPK1
RIPK1
PRJNA1217017 | ENA
ProteomicsPrimary mouse hepatocytes RIPK1 mass spectrometry
This project aims to identify the key methylation targets that are involved in RIPK1 activation.
ORGANISM(S): Mus musculus (Mouse) 
2025-07-27 | PXD064410 | Pride
Mass Primary mouse hepatocytes Ripk1 
TranscriptomicsTranscriptional profiles of PA1 teratoma cells transfected by RIPK1, RIPK2, RIPK3, or RIPK4
RIPK4 but not the related kinases RIPK1, RIPK2, and RIPK3 caused similar transcriptional changes to Wnt3a. PA1 cells were transfected by 8ug RIPK1, RIPK2, RIPK3, or RIPK4 for 48h, RNA were extracted and sequenced.
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-43362 | biostudies-arrayexpress
ProteomicsInhibition of TBK1/IKKe mediated RIPK1 phosphorylation sensitizes tumors to immune cell killing.
Resistance to immune cell-mediated cytotoxicity poses a significant challenge in cancer therapy, compromising the efficacy of immunotherapeutic approaches such as immune checkpoint blockade (ICB) treatment. To enhance therapy outcomes, it is crucial to identify interventions that can synergize with ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD062987 | Pride
Biotin ap Phosphorylation Tumors Tnf signaling Tbk1 Ripk1 
ProteomicsTyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a cytosolic protein kinase that regulates multiple inflammatory and cell death pathways. Serine/Threonine phosphorylation of RIPK1 is known to suppress RIPK1 kinase-mediated cell death in the contexts of inflammation, infection and em...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD036995 | Pride
Inflammation Phosphorylation Ripk1 Cell death 
ProteomicsSpecies-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation
we identify serine/threonine kinase 38 (STK38) as a novel direct RIPK1 activator. STK38 binds to RIPK1, integrates into RIPK1-containing death complexes, and promotes RIPK1-dependent cell death.
ORGANISM(S): Homo sapiens (Human) 
2026-07-10 | PXD066201 | Pride
Necroptosis Ripk3 Ripk1 Lc-ms/ms 
ProteomicsEvaluation of N8-propargyl spermidine and spermine as substrates of deoxyhypusine synthase in the in vitro hypusination of eIF5A and RIPK1
eIF5A is a well-established protein substrate of deoxyhypusine synthase (DHS), which also requires spermidine as a small-molecule substrate. At the end of 2024, a publication claimed that RIPK1 is an additional DHS substrate and that N8-propargyl spermidine can also serve as a DHS substrate. To eval...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD071577 | Pride
N8-propargyl spermidine Dhs Eif5a Chemical probe Hypusination Deoxyhypusine synthase Ripk1 
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