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MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
ProteomicsBiochemical profile of the A.thaliana hypusination pathway
The eukaryotic translation elongation factor eIF5A is the only protein known to contain the unusual amino acid hypusine which is essential for its biological activity. This posttranslational modification is achieved by the sequential action of the enzymes deoxyhypusine synthase and deoxyhypusine hyd...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-07-09 | PXD000880 | Pride
Spermidine Eif5a Abscisic acid 2d-electrophoresis Hypusine 
GenomicsPCa Hypusination
Study the role of the hypusination pathway in the progression of prostate cancer
PRJEB105064 | ENA
GenomicsProstate Cancer Hypusination
Study the role of the hypusination pathway in the progression of prostate cancer.
PRJEB104890 | ENA
GenomicsChemical genetic interaction linking eIF5A hypusination and mitochondrial integrity
Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity
PRJNA1106772 | ENA
GenomicsTargeting polyamine metabolism and eIF5A hypusination in pediatric acute myeloid leukemia
Targeting polyamine metabolism and eIF5A hypusination in pediatric acute myeloid leukemia
PRJNA1505732 | ENA
GenomicsThe eIF5A hypusination inhibitor GC7 acts as a mitochondrial stress inducer
The eIF5A hypusination inhibitor GC7 acts as a mitochondrial stress inducer
PRJNA1021181 | ENA
TranscriptomicsChemical genetic interaction linking eIF5A hypusination and mitochondrial integrity
The eukaryotic translation factor eIF5A plays an important role in translation elongation, especially across stretches of prolines and charged amino acids, and in translation termination. eIF5A undergoes hypusination, a post-translational modification unique to this protein, although the role of hyp...
ORGANISM(S): Homo sapiens 
2025-05-06 | GSE266331 | GEO
UnknownHypusination Orchestrates the Antimicrobial Response of Macrophages.
Not available
S-EPMC7812972 | biostudies-literature
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