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ProteomicsThe polyamine-hypusine circuit controls an oncogenic translational program necessary for MYC-driven lymphomagenesis
MYC oncogenes are activated in broad spectrum of human malignancies and transcriptionally reprogram the genome to drive cancer cell growth. Given this it is unclear if targeting a single effector will have a therapeutic benefit. MYC activates the polyaminehypusine circuit, which post-translationally...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD031361 | Pride
Tumorigenesis Lymphoma Eif5a Dhps Myc Polyamine-hypusine Translation 
ProteomicsHypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular fun...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD015424 | Pride
Polyamines Β cell Hypusine Proliferation 
Proteomics: Hypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
: Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular f...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015414 | Pride
Polyamines Β cell Hypusine Proliferation 
UnknownPosttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
Not available
S-EPMC2572820 | biostudies-literature
ProteomicsOxygen level regulates protein N-terminal translation elongation through deoxyhypusine hydroxylation
Hypusine is a post-translational modification on eukaryotic translation initiation factor 5A (eIF5A). The last step in the biosynthesis of hypusine, deoxyhypusine hydroxylation, is an oxygen dependent reaction. Here we show that deletion of deoxyhypusine hydroxylase, Lia1, compromises yeast respirat...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD032321 | Pride
Oxygen Silac Deoxyhupusine Hypusine 
TranscriptomicsTranscription profiling of S. cerevisiae temperature sensitive eIF5A mutant shows accumulation of transcripts targeted to the Nonsense Mediated Decay pathway
The highly conserved protein eIF5A found in archaea and all eucaryotes uniquely contains the posttranslationally formed amino acid hypusine. Despite being essential the functions of this protein and its modification remain unclear. To gain more insight into these functions temperature sensitive muta...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-13 | E-GEOD-5290 | biostudies-arrayexpress
UnknownFunctional significance of eIF5A and its hypusine modification in eukaryotes.
Not available
S-EPMC2829442 | biostudies-literature
UnknownHypusine, a polyamine-derived amino acid critical for eukaryotic translation.
Not available
S-EPMC6290153 | biostudies-literature
UnknownProtein-protein-interaction network organization of the hypusine modification system.
Not available
S-EPMC3494187 | biostudies-literature
UnknownBiological Relevance and Therapeutic Potential of the Hypusine Modification System.
Not available
S-EPMC4513096 | biostudies-literature
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