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ProteomicsHypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular fun...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD015424 | Pride
Polyamines Β cell Hypusine Proliferation 
Proteomics: Hypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
: Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular f...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015414 | Pride
Polyamines Β cell Hypusine Proliferation 
UnknownHypusine, a polyamine-derived amino acid critical for eukaryotic translation.
Not available
S-EPMC6290153 | biostudies-literature
UnknownModulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells.
Not available
S-EPMC10561731 | biostudies-literature
UnknownA tumour suppressor network relying on the polyamine-hypusine axis.
Not available
S-EPMC3530829 | biostudies-literature
GenomicsHypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
Hypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
PRJNA562726 | ENA
UnknownThe Polyamine-Hypusine Circuit Controls an Oncogenic Translational Program Essential for Malignant Conversion in MYC-Driven Lymphoma.
Not available
S-EPMC10320645 | biostudies-literature
UnknownAmino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis.
Not available
S-EPMC5737446 | biostudies-literature
ProteomicsThe polyamine-hypusine circuit controls an oncogenic translational program necessary for MYC-driven lymphomagenesis
MYC oncogenes are activated in broad spectrum of human malignancies and transcriptionally reprogram the genome to drive cancer cell growth. Given this it is unclear if targeting a single effector will have a therapeutic benefit. MYC activates the polyaminehypusine circuit, which post-translationally...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD031361 | Pride
Tumorigenesis Lymphoma Eif5a Dhps Myc Polyamine-hypusine Translation 
TranscriptomicsHypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular func...
ORGANISM(S): Mus musculus 
2019-08-30 | GSE136581 | GEO
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