Sort   by:  
 Page size 
ProteomicsA Polyamine-mediated Posttranslational Modification Required For Macrophage Tissue Residency – Differential proteome analysis of DHPS deficient macrophages
Tissue resident macrophages (MTRs) regulate tissue repair and homeostasis by clearing cell debris, and are thought to form the first line of defense against pathogens. MTRs form early in life and self-renew locally. However, during tissue damage or disease, bone-marrow derived monocytes enter tissue...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD054670 | Pride
Eif5a Dia Spectronaut Dda spectral library Tissue resident macrophage proteomics Maxquant Label-free quantification Deoxyhypusine synthase (dhps) Hypusine 
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
ProteomicsDeoxyhypusine synthase (DHPS) mutations alter the post-translational modification of eukaryotic initiation factor 5A (eIF5A) resulting in impaired human and mouse neural homeostasis
DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation by catalyzing the post-translational modification, and therefore activation, of the eukaryotic initiation factor 5A (eIF5A). The...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-06 | MSV000092112 | MassIVE
UnknownReplacing sulfa drugs with novel DHPS inhibitors.
Not available
S-EPMC3869102 | biostudies-literature
UnknowneIF5A-Independent Role of DHPS in p21CIP1 and Cell Fate Regulation.
Not available
S-EPMC8707118 | biostudies-literature
UnknownERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity.
Not available
S-EPMC11544350 | biostudies-literature
UnknownExtracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation.
Not available
S-EPMC7522278 | biostudies-literature
UnknownBidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer.
Not available
S-EPMC3434345 | biostudies-literature
ProteomicsEffect of Dhps deletion on macrophage activation by Helicobacter pylori
Bone marrow-derived macrophages from Dhps fl/fl mice and mice with specific deletion of Dhps in myeloid cells were infected with Helicobacter pylori PMSS1 for 24 hours. Cells were washed and lysed. Proteins were analyzed by isobaric tags for relative and absolute quantitation (iTRAQ).
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018187 | Pride
Macrophage Bacterial infection Helicobacter pylori 
UnknownPlasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya.
Not available
S-EPMC7725689 | biostudies-literature
Sort   by:  
 Page size