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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
MetabolomicsMaslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...
2017-02-09 | MTBLS240 | MetaboLights
MetabolomicsMultiomic analysis reveals a role of Fusobacterium periodonticum in colorectal tumorigenesis by decanoic acid promoting neutrophil chemotaxis
Gut microbiota dysbiosis and immune dysregulation are closely linked to colorectal cancer development. Identifying mechanistic connections among specific microbial species, metabolites, and immune responses may reveal novel insights into its pathogenesis. Here, employing metagenomic, metabolomic, an...
2026-05-20 | MTBLS14505 | MetaboLights
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
MetabolomicsA non-dividing population with high pyruvate dehydrogenase kinase activity drives metabolic heterogeneity and tumorigenesis in the intestine
Not available
ORGANISM(S): Mus musculus 
ST002072 | MetabolomicsWorkbench
TranscriptomicseIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
Translational regulation plays a critical role in cell growth and proliferation, and its dysregulation results in cancer. Aberrant expression of the mRNA 5’cap-binding protein, eIF4E, has been implicated in cancer development and progression. eIF4E activity is promoted by phosphorylation. Here we sh...
ORGANISM(S): Mus musculus 
2010-08-17 | E-GEOD-17451 | biostudies-arrayexpress
GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
While aneuploidy is found in more than 90% of solid tumors, it is unclear whether aneuploidy is the cause or the consequence of tumorigenesis. Different mouse models deficient in centrosomal or spindle checkpoint proteins that induce aneuploidy show either a promotion or a decrease in tumorigenesis ...
ORGANISM(S): Mus musculus 
2015-10-27 | E-MTAB-3733 | biostudies-arrayexpress
ProteomicsPRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
AKT is involved in a number of key cellular processes including cell proliferation, apoptosis and metabolism. Hyperactivation of AKT is associated with many pathological conditions, particularly cancers. Emerging evidence indicates that arginine methylation is involved in modulating AKT signaling pa...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026071 | Pride
Tumorigenesis Prmt5 Akt Arginine methylation 
TranscriptomicsEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors
This SuperSeries is composed of the following subset Series: GSE32727: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [human] GSE32904: EMT inducers catalyze malignant transformation of mammary epithelial cells and drive ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-32905 | biostudies-arrayexpress
TranscriptomicsMerlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4DCAF1, and supp...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-19305 | biostudies-arrayexpress
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